Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either sim...

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Detalles Bibliográficos
Autores principales: Almassinokiani, Fariba, Mehdizadeh, Abolfazl, Sariri, Elaheh, Rezaei, Mansour, Almasi, Alireza, Akbari, Hossein, Pazouki, Abdolreza, Solaymani-Dodaran, Masoud, Asadollah, Sara, Amirkhani, Jila, Chaichian, Shahla, Vahdat, Mansoureh, Moosavi, Ashrafsadat, Ashouri, Monir, Tamannaei, Zeinab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Product Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706410/
https://www.ncbi.nlm.nih.gov/pubmed/23828228
http://dx.doi.org/10.12659/MSM.883967
Descripción
Sumario:BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses. RESULTS: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05). CONCLUSIONS: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.

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