Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either sim...

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Autores principales: Almassinokiani, Fariba, Mehdizadeh, Abolfazl, Sariri, Elaheh, Rezaei, Mansour, Almasi, Alireza, Akbari, Hossein, Pazouki, Abdolreza, Solaymani-Dodaran, Masoud, Asadollah, Sara, Amirkhani, Jila, Chaichian, Shahla, Vahdat, Mansoureh, Moosavi, Ashrafsadat, Ashouri, Monir, Tamannaei, Zeinab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Product Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706410/
https://www.ncbi.nlm.nih.gov/pubmed/23828228
http://dx.doi.org/10.12659/MSM.883967
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author Almassinokiani, Fariba
Mehdizadeh, Abolfazl
Sariri, Elaheh
Rezaei, Mansour
Almasi, Alireza
Akbari, Hossein
Pazouki, Abdolreza
Solaymani-Dodaran, Masoud
Asadollah, Sara
Amirkhani, Jila
Chaichian, Shahla
Vahdat, Mansoureh
Moosavi, Ashrafsadat
Ashouri, Monir
Tamannaei, Zeinab
author_facet Almassinokiani, Fariba
Mehdizadeh, Abolfazl
Sariri, Elaheh
Rezaei, Mansour
Almasi, Alireza
Akbari, Hossein
Pazouki, Abdolreza
Solaymani-Dodaran, Masoud
Asadollah, Sara
Amirkhani, Jila
Chaichian, Shahla
Vahdat, Mansoureh
Moosavi, Ashrafsadat
Ashouri, Monir
Tamannaei, Zeinab
author_sort Almassinokiani, Fariba
collection PubMed
description BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses. RESULTS: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05). CONCLUSIONS: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.
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spelling pubmed-37064102013-07-11 Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis Almassinokiani, Fariba Mehdizadeh, Abolfazl Sariri, Elaheh Rezaei, Mansour Almasi, Alireza Akbari, Hossein Pazouki, Abdolreza Solaymani-Dodaran, Masoud Asadollah, Sara Amirkhani, Jila Chaichian, Shahla Vahdat, Mansoureh Moosavi, Ashrafsadat Ashouri, Monir Tamannaei, Zeinab Med Sci Monit Product Investigations BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses. RESULTS: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05). CONCLUSIONS: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis. International Scientific Literature, Inc. 2013-07-05 /pmc/articles/PMC3706410/ /pubmed/23828228 http://dx.doi.org/10.12659/MSM.883967 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Product Investigations
Almassinokiani, Fariba
Mehdizadeh, Abolfazl
Sariri, Elaheh
Rezaei, Mansour
Almasi, Alireza
Akbari, Hossein
Pazouki, Abdolreza
Solaymani-Dodaran, Masoud
Asadollah, Sara
Amirkhani, Jila
Chaichian, Shahla
Vahdat, Mansoureh
Moosavi, Ashrafsadat
Ashouri, Monir
Tamannaei, Zeinab
Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title_full Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title_fullStr Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title_full_unstemmed Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title_short Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
title_sort effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
topic Product Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706410/
https://www.ncbi.nlm.nih.gov/pubmed/23828228
http://dx.doi.org/10.12659/MSM.883967
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