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Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet

BACKGROUND: A low-carbohydrate, high-fat ketogenic diet (KD) induces hepatic ketogenesis and is believed to affect energy metabolism in mice. As hepatic Fgf21 expression was markedly induced in mice fed KD, we examined the effects of KD feeding on metabolism and the roles of Fgf21 in metabolism in m...

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Detalles Bibliográficos
Autores principales: Murata, Yusuke, Nishio, Kyoji, Mochiyama, Takayuki, Konishi, Morichika, Shimada, Masaya, Ohta, Hiroya, Itoh, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706421/
https://www.ncbi.nlm.nih.gov/pubmed/23874946
http://dx.doi.org/10.1371/journal.pone.0069330