Cargando…

Inhibition of Dual/Mixed Tropic HIV-1 Isolates by CCR5-Inhibitors in Primary Lymphocytes and Macrophages

BACKGROUND: Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Surdo, Matteo, Balestra, Emanuela, Saccomandi, Patrizia, Di Santo, Fabiola, Montano, Marco, Di Carlo, Domenico, Sarmati, Loredana, Aquaro, Stefano, Andreoni, Massimo, Svicher, Valentina, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706609/ https://www.ncbi.nlm.nih.gov/pubmed/23874501 http://dx.doi.org/10.1371/journal.pone.0068076

Ejemplares similares

T Lymphocyte Subset Counts and Interferon-Gamma Production in Adults and Children with COVID-19: A Narrative Review
por: De Rose, Domenico Umberto, et al.
Publicado: (2023)

A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition In Vitro
por: Salpini, Romina, et al.
Publicado: (2020)

An Increase in the Levels of Middle Surface Antigen Characterizes Patients Developing HBV-Driven Liver Cancer Despite Prolonged Virological Suppression
por: Brancaccio, Giuseppina, et al.
Publicado: (2021)

A Very Low Geno2pheno False Positive Rate Is Associated with Poor Viro-Immunological Response in Drug-Naïve Patients Starting a First-Line HAART
por: Armenia, Daniele, et al.
Publicado: (2014)

Different Patterns of HIV-1 Replication in MACROPHAGES is Led by Co-Receptor Usage
por: Borrajo, Ana, et al.
Publicado: (2019)

Selected amino acid mutations in HIV-1 B subtype gp41 are Associated with Specific gp120(V3 )signatures in the regulation of Co-Receptor usage
por: Dimonte, Salvatore, et al.
Publicado: (2011)

Long-Term SARS-CoV-2 Infection Associated with Viral Dissemination in Different Body Fluids Including Bile in Two Patients with Acute Cholecystitis
por: Scutari, Rossana, et al.
Publicado: (2020)

HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients
por: Malagnino, Vincenzo, et al.
Publicado: (2020)

The Role of HIV Infection in Neurologic Injury
por: Scutari, Rossana, et al.
Publicado: (2017)

Impact of HIV-1 tropism on the emergence of non-AIDS events in HIV-infected patients receiving fully suppressive antiretroviral therapy
por: Maffongelli, Gaetano, et al.
Publicado: (2016)

Highly Sensitive HBsAg, Anti-HBc and Anti HBsAg Titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive Onco-Haematological Patients
por: Cerva, Carlotta, et al.
Publicado: (2022)

A stable CC-chemokine receptor (CCR)-5 tropic virus is correlated with the persistence of HIV RNA at less than 2.5 copies in successfully treated naïve subjects
por: Parisi, Saverio Giuseppe, et al.
Publicado: (2013)

High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance
por: Malagnino, Vincenzo, et al.
Publicado: (2018)

Cryptic HBV Replicative Activity Is Frequently Revealed in Anti-HBc-Positive/HBsAg-Negative Patients with HIV Infection by Highly Sensitive Molecular Assays, and Can Be Predicted by Integrating Classical and Novel Serological HBV Markers
por: Salpini, Romina, et al.
Publicado: (2020)

Editorial: Novel Concepts in Mechanisms Modulating HBV Persistence, Pathogenesis, and Oncogenetic Properties
por: Svicher, Valentina, et al.
Publicado: (2021)

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
por: Svicher, Valentina, et al.
Publicado: (2021)

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection
por: Salpini, Romina, et al.
Publicado: (2020)

HCV Genotypes Are Differently Prone to the Development of Resistance to Linear and Macrocyclic Protease Inhibitors
por: Cento, Valeria, et al.
Publicado: (2012)

Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence
por: Alteri, Claudia, et al.
Publicado: (2018)

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro
por: Salpini, Romina, et al.
Publicado: (2017)

Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug Withdrawal in Chronically-Infected Monocytes/Macrophages
por: Borrajo, Ana, et al.
Publicado: (2017)

CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy
por: Grande, Fedora, et al.
Publicado: (2019)

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b
por: Alkhatib, Mohammad, et al.
Publicado: (2021)

Description of the L76V Resistance Protease Mutation in HIV-1 B and “Non-B” Subtypes
por: Charpentier, Charlotte, et al.
Publicado: (2013)

280. Monoclonal Antibodies Against SARS-CoV-2 in Fragile Outpatients: Clinical and Laboratory Risk Factors and Protective Role of Vaccination
por: Cavasio, Rosario Alessandro, et al.
Publicado: (2022)

Frequency of Atypical Mutations in the Spike Glycoprotein in SARS-CoV-2 Circulating from July 2020 to July 2022 in Central Italy: A Refined Analysis by Next Generation Sequencing
por: Bellocchi, Maria Concetta, et al.
Publicado: (2023)

The Genotypic False Positive Rate Determined by V3 Population Sequencing Can Predict the Burden of HIV-1 CXCR4-using Species Detected by Pyrosequencing
por: Svicher, Valentina, et al.
Publicado: (2013)

Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs
por: Alteri, Claudia, et al.
Publicado: (2009)

Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report
por: Foroghi Biland, Luca, et al.
Publicado: (2019)

SARS-CoV-2 Mutations and Variants May Muddle the Sensitivity of COVID-19 Diagnostic Assays
por: Alkhatib, Mohammad, et al.
Publicado: (2022)

Phosphatidylcholine Liposomes Down-Modulate CD4 Expression Reducing HIV Entry in Human Type-1 Macrophages
por: De Santis, Federica, et al.
Publicado: (2022)

Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients
por: Gratteri, Carmen, et al.
Publicado: (2023)

Evaluation of HIV Transmission Clusters among Natives and Foreigners Living in Italy
por: Fabeni, Lavinia, et al.
Publicado: (2020)

HIV Replication at Low Copy Number and its Correlation with the HIV Reservoir: A Clinical Perspective
por: Sarmati, Loredana, et al.
Publicado: (2015)

Consequences of inaccurate hepatitis C virus genotyping on the costs of prescription of direct antiviral agents in an Italian district
por: Polilli, Ennio, et al.
Publicado: (2016)

HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation
por: Piermatteo, Lorenzo, et al.
Publicado: (2021)

New Markers in Monitoring the Reactivation of Hepatitis B Virus Infection in Immunocompromised Hosts
por: Svicher, Valentina, et al.
Publicado: (2019)

HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets
por: Colagrossi, Luna, et al.
Publicado: (2018)

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients
por: Balestrieri, Emanuela, et al.
Publicado: (2021)

New insights into hepatitis B virus lymphotropism: Implications for HBV-related lymphomagenesis
por: Svicher, Valentina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f5i6kuqklh0q9e9g7pfunj9sms