Cargando…

Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus

CONTEXT: The stepwise hyperglycemic clamp procedure (SHCP) is the gold standard for measuring the renal threshold for glucose excretion (RT(G)), but its use is limited to small studies in specialized laboratories. OBJECTIVE: The objective of the study was to validate a new method for determining RT(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Polidori, David, Sha, Sue, Ghosh, Atalanta, Plum-Mörschel, Leona, Heise, Tim, Rothenberg, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2013
Materias:	JCEM Online: Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706739/ https://www.ncbi.nlm.nih.gov/pubmed/23585665 http://dx.doi.org/10.1210/jc.2012-4205

Ejemplares similares

Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion: Results of a randomized, placebo-controlled study
por: Polidori, David, et al.
Publicado: (2013)

Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double‐blind, crossover study
por: Sha, S., et al.
Publicado: (2015)

Pharmacodynamic Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, from a Randomized Study in Patients with Type 2 Diabetes
por: Sha, Sue, et al.
Publicado: (2014)

Safety, tolerability, pharmacodynamics and pharmacokinetics following once‐daily doses of BI 187004, an inhibitor of 11 beta‐hydroxysteroid dehydrogenase‐1, over 28 days in patients with type 2 diabetes mellitus and overweight or obesity
por: Bianzano, Susanna, et al.
Publicado: (2022)

The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects
por: Halberg, Inge B., et al.
Publicado: (2019)

Genetically Determined Dosage of Follicle-Stimulating Hormone (FSH) Affects Male Reproductive Parameters
por: Grigorova, Marina, et al.
Publicado: (2011)

Mitochondrial Oxidative Phosphorylation Is Impaired in Patients with Congenital Lipodystrophy
por: Sleigh, Alison, et al.
Publicado: (2012)

Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency
por: Krone, Nils, et al.
Publicado: (2012)

Genome-Wide Homozygosity Analysis Reveals HADH Mutations as a Common Cause of Diazoxide-Responsive Hyperinsulinemic-Hypoglycemia in Consanguineous Pedigrees
por: Flanagan, Sarah E., et al.
Publicado: (2011)

An Atypical Case of Familial Glucocorticoid Deficiency without Pigmentation Caused by Coexistent Homozygous Mutations in MC2R (T152K) and MC1R (R160W)
por: Turan, Serap, et al.
Publicado: (2012)

A Missense Mutation in the Human Cytochrome b5 Gene causes 46,XY Disorder of Sex Development due to True Isolated 17,20 Lyase Deficiency
por: Idkowiak, Jan, et al.
Publicado: (2012)

Higher Levels of IGF-I and Adrenal Androgens at Age 8 Years Are Associated with Earlier Age at Menarche in Girls
por: Thankamony, Ajay, et al.
Publicado: (2012)

Variations in PROKR2, But Not PROK2, Are Associated With Hypopituitarism and Septo-optic Dysplasia
por: McCabe, Mark J., et al.
Publicado: (2013)

Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men
por: Nookaew, Intawat, et al.
Publicado: (2013)

Novel Associations in Disorders of Sex Development: Findings From the I-DSD Registry
por: Cox, Kathryn, et al.
Publicado: (2014)

A Novel Albumin Gene Mutation (R222I) in Familial Dysalbuminemic Hyperthyroxinemia
por: Schoenmakers, Nadia, et al.
Publicado: (2014)

Serum Estradiol Levels Are Inversely Associated With Cortical Porosity in Older Men
por: Vandenput, Liesbeth, et al.
Publicado: (2014)

Reclassification of Diabetes Etiology in a Family With Multiple Diabetes Phenotypes
por: Kavvoura, Fotini K., et al.
Publicado: (2014)

Thioredoxin Reductase 2 (TXNRD2) Mutation Associated With Familial Glucocorticoid Deficiency (FGD)
por: Prasad, Rathi, et al.
Publicado: (2014)

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma
por: Wang, Na, et al.
Publicado: (2014)

Elevated Peritoneal Expression and Estrogen Regulation of Nociceptive Ion Channels in Endometriosis
por: Greaves, Erin, et al.
Publicado: (2014)

Five-Year Follow-Up for Women With Subclinical Hypothyroidism in Pregnancy
por: Shields, Beverley M., et al.
Publicado: (2013)

Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men
por: Ohlsson, Claes, et al.
Publicado: (2013)

Genotype-Phenotype Correlation in 153 Adult Patients With Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: Analysis of the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) Cohort
por: Krone, Nils, et al.
Publicado: (2013)

Determination of Reference Intervals for Serum Total Calcium in the Vitamin D-Replete Pediatric Population
por: Roizen, Jeffrey D., et al.
Publicado: (2013)

Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome
por: Deal, Cheri L., et al.
Publicado: (2013)

Anatabine Supplementation Decreases Thyroglobulin Antibodies in Patients With Chronic Lymphocytic Autoimmune (Hashimoto's) Thyroiditis: A Randomized Controlled Clinical Trial
por: Schmeltz, Lowell R., et al.
Publicado: (2014)

Prenatal Diagnosis of Congenital Adrenal Hyperplasia Caused by P450 Oxidoreductase Deficiency
por: Reisch, Nicole, et al.
Publicado: (2013)

Structural Pituitary Abnormalities Associated With CHARGE Syndrome
por: Gregory, Louise C., et al.
Publicado: (2013)

Genetic and Epigenetic Modulation of Growth Hormone Sensitivity Studied With the IGF-1 Generation Test
por: Ouni, Meriem, et al.
Publicado: (2015)

PAPSS2 Deficiency Causes Androgen Excess via Impaired DHEA Sulfation—In Vitro and in Vivo Studies in a Family Harboring Two Novel PAPSS2 Mutations
por: Oostdijk, Wilma, et al.
Publicado: (2015)

Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers
por: Hernández-Ramírez, Laura C., et al.
Publicado: (2015)

NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings With Familial Glucocorticoid Deficiency
por: Novoselova, Tatiana V., et al.
Publicado: (2015)

Duration of Diabetes Predicts Aortic Pulse Wave Velocity and Vascular Events in Alström Syndrome
por: Paisey, Richard B., et al.
Publicado: (2015)

Obesity-Associated Melanocortin-4 Receptor Mutations Are Associated With Changes in the Brain Response to Food Cues
por: van der Klaauw, Agatha A., et al.
Publicado: (2014)

Heterogeneous Genetic Background of the Association of Pheochromocytoma/Paraganglioma and Pituitary Adenoma: Results From a Large Patient Cohort
por: Dénes, Judit, et al.
Publicado: (2015)

Expanding the Clinical Spectrum Associated With GLIS3 Mutations
por: Dimitri, P., et al.
Publicado: (2015)

An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children
por: Mäkinen, Marjaana, et al.
Publicado: (2014)

Hypoglycemia Risk Related to Double Dose Is Markedly Reduced with Basal Insulin Peglispro Versus Insulin Glargine in Patients with Type 2 Diabetes Mellitus in a Randomized Trial: IMAGINE 8
por: Harris, Cynthia, et al.
Publicado: (2017)

Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models
por: Liang, Yin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_83rb657bq8v06uvpdp2d7ma5c5