A Genetic Progression Model of Braf(V600E)-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

We show that BRAF(V600E) initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs with distinctive pathomorphologic/genetic/epidemiologic/clinical characteristics. Genetic and fu...

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Detalles Bibliográficos
Autores principales: Rad, Roland, Cadiñanos, Juan, Rad, Lena, Varela, Ignacio, Strong, Alexander, Kriegl, Lydia, Constantino-Casas, Fernando, Eser, Stefan, Hieber, Maren, Seidler, Barbara, Price, Stacey, Fraga, Mario F., Calvanese, Vincenzo, Hoffman, Gary, Ponstingl, Hannes, Schneider, Günter, Yusa, Kosuke, Grove, Carolyn, Schmid, Roland M., Wang, Wei, Vassiliou, George, Kirchner, Thomas, McDermott, Ultan, Liu, Pentao, Saur, Dieter, Bradley, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706745/
https://www.ncbi.nlm.nih.gov/pubmed/23845441
http://dx.doi.org/10.1016/j.ccr.2013.05.014

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