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Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy

Background and Purpose: Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate...

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Autores principales: Leonards, Christopher O., Wang, Li, Fiebach, Jochen B., Endres, Matthias, Ebinger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706746/
https://www.ncbi.nlm.nih.gov/pubmed/23847590
http://dx.doi.org/10.3389/fneur.2013.00092
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author Leonards, Christopher O.
Wang, Li
Fiebach, Jochen B.
Endres, Matthias
Ebinger, Martin
author_facet Leonards, Christopher O.
Wang, Li
Fiebach, Jochen B.
Endres, Matthias
Ebinger, Martin
author_sort Leonards, Christopher O.
collection PubMed
description Background and Purpose: Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacunes. Methods: All first ischemic stroke patients who completed a novel combined oral triglyceride and glucose tolerance test and MRI between January 2009 and June 2012 were included. Fluid-attenuated inversion recovery or T2 MRI sequences were used to visualize cavitating lacunes and white matter hyperintensities, which were graded using the Wahlund visual scale. Results: One hundred and ninety patients were included (median age 66, IQR 52–73; 33% female; median National Institute of Health Stroke Scale 2, IQR 1–4). A forward stepwise binary logistical regression analysis applying the Hosmer–Lemeshow goodness of fit test adjusted for parameters significant in univariate analyses (at the p < 0.10 level) revealed that Wahlund scores (Wahlund 0–4: reference; Wahlund 5–10: adjusted odds ratio, 5.1; 95% confidence interval, 1.3–20.0, p = 0.019; Wahlund>10: adjusted odds ratio 9.6; 95% CI, 1.55–59.35; p = 0.015) and the highest quartile of post-challenge triglycerides (>295 mg/dL; adjusted odds ratio, 7.36; 95% confidence interval 1.24–43.70; p = 0.028) independently associated with the presence of cavitating lacunes. Conclusion: Post-challenge serum triglycerides are independently associated with the presence of cavitating lacunes.
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spelling pubmed-37067462013-07-11 Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy Leonards, Christopher O. Wang, Li Fiebach, Jochen B. Endres, Matthias Ebinger, Martin Front Neurol Neuroscience Background and Purpose: Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacunes. Methods: All first ischemic stroke patients who completed a novel combined oral triglyceride and glucose tolerance test and MRI between January 2009 and June 2012 were included. Fluid-attenuated inversion recovery or T2 MRI sequences were used to visualize cavitating lacunes and white matter hyperintensities, which were graded using the Wahlund visual scale. Results: One hundred and ninety patients were included (median age 66, IQR 52–73; 33% female; median National Institute of Health Stroke Scale 2, IQR 1–4). A forward stepwise binary logistical regression analysis applying the Hosmer–Lemeshow goodness of fit test adjusted for parameters significant in univariate analyses (at the p < 0.10 level) revealed that Wahlund scores (Wahlund 0–4: reference; Wahlund 5–10: adjusted odds ratio, 5.1; 95% confidence interval, 1.3–20.0, p = 0.019; Wahlund>10: adjusted odds ratio 9.6; 95% CI, 1.55–59.35; p = 0.015) and the highest quartile of post-challenge triglycerides (>295 mg/dL; adjusted odds ratio, 7.36; 95% confidence interval 1.24–43.70; p = 0.028) independently associated with the presence of cavitating lacunes. Conclusion: Post-challenge serum triglycerides are independently associated with the presence of cavitating lacunes. Frontiers Media S.A. 2013-07-10 /pmc/articles/PMC3706746/ /pubmed/23847590 http://dx.doi.org/10.3389/fneur.2013.00092 Text en Copyright © 2013 Leonards, Wang, Fiebach, Endres and Ebinger. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Leonards, Christopher O.
Wang, Li
Fiebach, Jochen B.
Endres, Matthias
Ebinger, Martin
Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title_full Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title_fullStr Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title_full_unstemmed Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title_short Fasting Versus Post-Challenge Triglycerides and Pre-Existing Cavitating Lacunes: A Berlin “Cream & Sugar” Substudy
title_sort fasting versus post-challenge triglycerides and pre-existing cavitating lacunes: a berlin “cream & sugar” substudy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706746/
https://www.ncbi.nlm.nih.gov/pubmed/23847590
http://dx.doi.org/10.3389/fneur.2013.00092
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