Cargando…

CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory

In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting memory Th cells. In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM me...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanazawa, Asami, Löhning, Max, Radbruch, Andreas, Tokoyoda, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706785/
https://www.ncbi.nlm.nih.gov/pubmed/23847623
http://dx.doi.org/10.3389/fimmu.2013.00183
_version_ 1782276405290074112
author Hanazawa, Asami
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
author_facet Hanazawa, Asami
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
author_sort Hanazawa, Asami
collection PubMed
description In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting memory Th cells. In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM memory Th cells. Here we review recent evidence that CD69 and CD49b control homing of memory Th cell precursors to the BM. During the effector phase of an immune response, about 10% of activated CD4 T cells in the spleen express both CD69 and CD49b, and thus qualify as precursors of resting memory Th cells of BM. Loss or blockade of CD69 and CD49b expression on CD4 T cells impairs the generation of resting memory Th cells in the BM. Moreover, in the absence of BM memory Th cells in CD69-deficient mice, T-cell help for B cells is impaired, confirming the central role of BM memory Th cells in the maintenance of immunological memory.
format Online
Article
Text
id pubmed-3706785
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-37067852013-07-11 CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory Hanazawa, Asami Löhning, Max Radbruch, Andreas Tokoyoda, Koji Front Immunol Immunology In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting memory Th cells. In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM memory Th cells. Here we review recent evidence that CD69 and CD49b control homing of memory Th cell precursors to the BM. During the effector phase of an immune response, about 10% of activated CD4 T cells in the spleen express both CD69 and CD49b, and thus qualify as precursors of resting memory Th cells of BM. Loss or blockade of CD69 and CD49b expression on CD4 T cells impairs the generation of resting memory Th cells in the BM. Moreover, in the absence of BM memory Th cells in CD69-deficient mice, T-cell help for B cells is impaired, confirming the central role of BM memory Th cells in the maintenance of immunological memory. Frontiers Media S.A. 2013-07-10 /pmc/articles/PMC3706785/ /pubmed/23847623 http://dx.doi.org/10.3389/fimmu.2013.00183 Text en Copyright © 2013 Hanazawa, Löhning, Radbruch and Tokoyoda. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Hanazawa, Asami
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title_full CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title_fullStr CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title_full_unstemmed CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title_short CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory
title_sort cd49b/cd69-dependent generation of resting t helper cell memory
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706785/
https://www.ncbi.nlm.nih.gov/pubmed/23847623
http://dx.doi.org/10.3389/fimmu.2013.00183
work_keys_str_mv AT hanazawaasami cd49bcd69dependentgenerationofrestingthelpercellmemory
AT lohningmax cd49bcd69dependentgenerationofrestingthelpercellmemory
AT radbruchandreas cd49bcd69dependentgenerationofrestingthelpercellmemory
AT tokoyodakoji cd49bcd69dependentgenerationofrestingthelpercellmemory