The Integrated Web Portal for Escalation with Overdose Control (EWOC)

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding soft...

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Detalles Bibliográficos
Autores principales: Wang, Haibin, Tighiouart, Mourad, Huang, Shao-Chi, Berel, Dror, Cook-Wiens, Galen, Bresee, Catherine, Li, Quanlin, Rogatko, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706802/
https://www.ncbi.nlm.nih.gov/pubmed/23847696
http://dx.doi.org/10.2174/1874431120130427001
Descripción
Sumario:In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.

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