Cargando…
Genes and epigenetic processes as prospective pain targets
Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mecha...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706821/ https://www.ncbi.nlm.nih.gov/pubmed/23409739 http://dx.doi.org/10.1186/gm416 |
_version_ | 1782276413397663744 |
---|---|
author | Crow, Megan Denk, Franziska McMahon, Stephen B |
author_facet | Crow, Megan Denk, Franziska McMahon, Stephen B |
author_sort | Crow, Megan |
collection | PubMed |
description | Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. |
format | Online Article Text |
id | pubmed-3706821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37068212014-02-15 Genes and epigenetic processes as prospective pain targets Crow, Megan Denk, Franziska McMahon, Stephen B Genome Med Review Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. BioMed Central 2013-02-15 /pmc/articles/PMC3706821/ /pubmed/23409739 http://dx.doi.org/10.1186/gm416 Text en Copyright © 2013 BioMed Central Ltd |
spellingShingle | Review Crow, Megan Denk, Franziska McMahon, Stephen B Genes and epigenetic processes as prospective pain targets |
title | Genes and epigenetic processes as prospective pain targets |
title_full | Genes and epigenetic processes as prospective pain targets |
title_fullStr | Genes and epigenetic processes as prospective pain targets |
title_full_unstemmed | Genes and epigenetic processes as prospective pain targets |
title_short | Genes and epigenetic processes as prospective pain targets |
title_sort | genes and epigenetic processes as prospective pain targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706821/ https://www.ncbi.nlm.nih.gov/pubmed/23409739 http://dx.doi.org/10.1186/gm416 |
work_keys_str_mv | AT crowmegan genesandepigeneticprocessesasprospectivepaintargets AT denkfranziska genesandepigeneticprocessesasprospectivepaintargets AT mcmahonstephenb genesandepigeneticprocessesasprospectivepaintargets |