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Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

BACKGROUND: Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate the hepatic uptake of endogenous compounds like bile acids and of drugs, for example, the lipid-lowering atorvastatin, thereby influencing hepatobiliary elimination. Her...

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Detalles Bibliográficos
Autores principales:	Nies, Anne T, Niemi, Mikko, Burk, Oliver, Winter, Stefan, Zanger, Ulrich M, Stieger, Bruno, Schwab, Matthias, Schaeffeler, Elke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706890/ https://www.ncbi.nlm.nih.gov/pubmed/23311897 http://dx.doi.org/10.1186/gm405

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