Cargando…

Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes

Adipocytes hypertrophy is the main cause of obesity and its affliction such as type 2 diabetes (T2D). Since superparamagnetic iron oxide nanoparticles (SPIONs) are used for a wide range of biomedical/medical applications, we aimed to study the effect of SPIONs on 22 and 29 risk genes (Based on gene...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharifi, S., Daghighi, S., Motazacker, M. M., Badlou, B., Sanjabi, B., Akbarkhanzadeh, A., Rowshani, A. T., Laurent, S., Peppelenbosch, M. P., Rezaee, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707025/
https://www.ncbi.nlm.nih.gov/pubmed/23838847
http://dx.doi.org/10.1038/srep02173
_version_ 1782276454994673664
author Sharifi, S.
Daghighi, S.
Motazacker, M. M.
Badlou, B.
Sanjabi, B.
Akbarkhanzadeh, A.
Rowshani, A. T.
Laurent, S.
Peppelenbosch, M. P.
Rezaee, F.
author_facet Sharifi, S.
Daghighi, S.
Motazacker, M. M.
Badlou, B.
Sanjabi, B.
Akbarkhanzadeh, A.
Rowshani, A. T.
Laurent, S.
Peppelenbosch, M. P.
Rezaee, F.
author_sort Sharifi, S.
collection PubMed
description Adipocytes hypertrophy is the main cause of obesity and its affliction such as type 2 diabetes (T2D). Since superparamagnetic iron oxide nanoparticles (SPIONs) are used for a wide range of biomedical/medical applications, we aimed to study the effect of SPIONs on 22 and 29 risk genes (Based on gene wide association studies) for obesity and T2D in human adipocytes. The mRNA expression of lipid and glucose metabolism genes was changed upon the treatment of human primary adipocytes with SPIONs. mRNA of GULP1, SLC30A8, NEGR1, SEC16B, MTCH2, MAF, MC4R, and TMEM195 were severely induced, whereas INSIG2, NAMPT, MTMR9, PFKP, KCTD15, LPL and GNPDA2 were down-regulated upon SPIONs stimulation. Since SEC16B gene assist the phagocytosis of apoptotic cells and this gene were highly expressed upon SPIONs treatment in adipocytes, it is logic to assume that SPIONs may play a crucial role in this direction, which requires more consideration in the future.
format Online
Article
Text
id pubmed-3707025
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-37070252013-07-10 Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes Sharifi, S. Daghighi, S. Motazacker, M. M. Badlou, B. Sanjabi, B. Akbarkhanzadeh, A. Rowshani, A. T. Laurent, S. Peppelenbosch, M. P. Rezaee, F. Sci Rep Article Adipocytes hypertrophy is the main cause of obesity and its affliction such as type 2 diabetes (T2D). Since superparamagnetic iron oxide nanoparticles (SPIONs) are used for a wide range of biomedical/medical applications, we aimed to study the effect of SPIONs on 22 and 29 risk genes (Based on gene wide association studies) for obesity and T2D in human adipocytes. The mRNA expression of lipid and glucose metabolism genes was changed upon the treatment of human primary adipocytes with SPIONs. mRNA of GULP1, SLC30A8, NEGR1, SEC16B, MTCH2, MAF, MC4R, and TMEM195 were severely induced, whereas INSIG2, NAMPT, MTMR9, PFKP, KCTD15, LPL and GNPDA2 were down-regulated upon SPIONs stimulation. Since SEC16B gene assist the phagocytosis of apoptotic cells and this gene were highly expressed upon SPIONs treatment in adipocytes, it is logic to assume that SPIONs may play a crucial role in this direction, which requires more consideration in the future. Nature Publishing Group 2013-07-10 /pmc/articles/PMC3707025/ /pubmed/23838847 http://dx.doi.org/10.1038/srep02173 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Sharifi, S.
Daghighi, S.
Motazacker, M. M.
Badlou, B.
Sanjabi, B.
Akbarkhanzadeh, A.
Rowshani, A. T.
Laurent, S.
Peppelenbosch, M. P.
Rezaee, F.
Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title_full Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title_fullStr Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title_full_unstemmed Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title_short Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
title_sort superparamagnetic iron oxide nanoparticles alter expression of obesity and t2d-associated risk genes in human adipocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707025/
https://www.ncbi.nlm.nih.gov/pubmed/23838847
http://dx.doi.org/10.1038/srep02173
work_keys_str_mv AT sharifis superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT daghighis superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT motazackermm superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT badloub superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT sanjabib superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT akbarkhanzadeha superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT rowshaniat superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT laurents superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT peppelenboschmp superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes
AT rezaeef superparamagneticironoxidenanoparticlesalterexpressionofobesityandt2dassociatedriskgenesinhumanadipocytes