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Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under varyin...

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Detalles Bibliográficos
Autores principales:	Nowak, Katarzyna, Seisenbacher, Gerhard, Hafen, Ernst, Stocker, Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707060/ https://www.ncbi.nlm.nih.gov/pubmed/23853709 http://dx.doi.org/10.7554/eLife.00380

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