Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

The tumor suppressor PIP(3) phosphatase PTEN is phosphorylated on four clustered Ser/Thr on its C-terminal tail (aa 380–385) and these phosphorylations are proposed to induce a reduction in PTEN’s plasma membrane recruitment. How these phosphorylations affect the structure and enzymatic function of...

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Detalles Bibliográficos
Autores principales: Bolduc, David, Rahdar, Meghdad, Tu-Sekine, Becky, Sivakumaren, Sindhu Carmen, Raben, Daniel, Amzel, L Mario, Devreotes, Peter, Gabelli, Sandra B, Cole, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707082/
https://www.ncbi.nlm.nih.gov/pubmed/23853711
http://dx.doi.org/10.7554/eLife.00691

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