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Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies
Malignant gliomas are the most common primary brain tumors. Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy. There is substantial presence of microglia...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707269/ https://www.ncbi.nlm.nih.gov/pubmed/23864876 http://dx.doi.org/10.1155/2013/264124 |
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author | Carvalho da Fonseca, Anna Carolina Badie, Behnam |
author_facet | Carvalho da Fonseca, Anna Carolina Badie, Behnam |
author_sort | Carvalho da Fonseca, Anna Carolina |
collection | PubMed |
description | Malignant gliomas are the most common primary brain tumors. Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy. There is substantial presence of microglia and macrophages within and surrounding brain tumors. These immune cells acquire an alternatively activated phenotype with potent tumor-tropic functions that contribute to glioma growth and invasion. In this review, we briefly summarize recent data that has been reported on the interaction of microglia/macrophages with brain tumors and discuss potential application of these findings to the development of future antiglioma therapies. |
format | Online Article Text |
id | pubmed-3707269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37072692013-07-17 Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies Carvalho da Fonseca, Anna Carolina Badie, Behnam Clin Dev Immunol Review Article Malignant gliomas are the most common primary brain tumors. Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy. There is substantial presence of microglia and macrophages within and surrounding brain tumors. These immune cells acquire an alternatively activated phenotype with potent tumor-tropic functions that contribute to glioma growth and invasion. In this review, we briefly summarize recent data that has been reported on the interaction of microglia/macrophages with brain tumors and discuss potential application of these findings to the development of future antiglioma therapies. Hindawi Publishing Corporation 2013 2013-06-25 /pmc/articles/PMC3707269/ /pubmed/23864876 http://dx.doi.org/10.1155/2013/264124 Text en Copyright © 2013 A. C. Carvalho da Fonseca and B. Badie. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Carvalho da Fonseca, Anna Carolina Badie, Behnam Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title | Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title_full | Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title_fullStr | Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title_full_unstemmed | Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title_short | Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies |
title_sort | microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707269/ https://www.ncbi.nlm.nih.gov/pubmed/23864876 http://dx.doi.org/10.1155/2013/264124 |
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