PI3K regulation of the SKP-2/p27 axis through mTORC2

The cyclin dependent kinase inhibitor p27 is a key regulator of cell cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase associated protein 2 (SKP-2) is an F-b...

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Detalles Bibliográficos
Autores principales: Shanmugasundaram, Karthigayan, Block, Karen, Nayak, Bijaya K., Livi, Carolina B., Venkatachalam, Manjeri A., Sudarshan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707507/
https://www.ncbi.nlm.nih.gov/pubmed/22733130
http://dx.doi.org/10.1038/onc.2012.226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707507/
https://www.ncbi.nlm.nih.gov/pubmed/22733130
http://dx.doi.org/10.1038/onc.2012.226

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