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Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

Glucose-dependent insulinotropic polypeptide (GIP) is an endogenous hormonal factor (incretin) that, upon binding to its receptor (GIPr; a class B G-protein-coupled receptor), stimulates insulin secretion by beta cells in the pancreas. There has been a lack of potent inhibitors of the GIPr with prol...

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Detalles Bibliográficos
Autores principales:	Ravn, Peter, Madhurantakam, Chaithanya, Kunze, Susan, Matthews, Evelyn, Priest, Claire, O'Brien, Siobhan, Collinson, Andie, Papworth, Monika, Fritsch-Fredin, Maria, Jermutus, Lutz, Benthem, Lambertus, Gruetter, Markus, Jackson, Ronald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707680/ https://www.ncbi.nlm.nih.gov/pubmed/23689510 http://dx.doi.org/10.1074/jbc.M112.426288

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