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The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study

BACKGROUND: Meat quality is an important economic trait in chickens. To identify loci and genes associated with meat quality traits, we conducted a genome-wide association study (GWAS) of F2 populations derived from a local Chinese breed (Beijing-You chickens) and a commercial fast-growing broiler l...

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Autores principales: Sun, Yanfa, Zhao, Guiping, Liu, Ranran, Zheng, Maiqing, Hu, Yaodong, Wu, Dan, Zhang, Lei, Li, Peng, Wen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707761/
https://www.ncbi.nlm.nih.gov/pubmed/23834466
http://dx.doi.org/10.1186/1471-2164-14-458
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author Sun, Yanfa
Zhao, Guiping
Liu, Ranran
Zheng, Maiqing
Hu, Yaodong
Wu, Dan
Zhang, Lei
Li, Peng
Wen, Jie
author_facet Sun, Yanfa
Zhao, Guiping
Liu, Ranran
Zheng, Maiqing
Hu, Yaodong
Wu, Dan
Zhang, Lei
Li, Peng
Wen, Jie
author_sort Sun, Yanfa
collection PubMed
description BACKGROUND: Meat quality is an important economic trait in chickens. To identify loci and genes associated with meat quality traits, we conducted a genome-wide association study (GWAS) of F2 populations derived from a local Chinese breed (Beijing-You chickens) and a commercial fast-growing broiler line (Cobb-Vantress). RESULTS: In the present study, 33 association signals were detected from the compressed mixed linear model (MLM) for 10 meat quality traits: dry matter in breast muscle (DM(Br)), dry matter in thigh muscle (DM(Th)), intramuscular fat content in breast muscle (IMF(Br)), meat color lightness (L*) and yellowness (b*) values, skin color L*, a* (redness) and b* values, abdominal fat weight (AbFW) and AbFW as a percentage of eviscerated weight (AbFP). Relative expressions of candidate genes identified near significant signals were compared using samples of chickens with High and Low phenotypic values. A total of 14 genes associated with IMF(Br), meat color L*, AbFW, and AbFP, were differentially expressed between the High and Low phenotypic groups. These genes are, therefore, prospective candidate genes for meat quality traits: protein tyrosine kinase (TYRO3) and microsomal glutathione S-transferase 1 (MGST1) for IMF(Br); collagen, type I, alpha 2 (COL1A2) for meat color L*; and RET proto-oncogene (RET), natriuretic peptide B (NPPB) and sterol regulatory element binding transcription factor 1 (SREBF1) for the abdominal fat (AbF) traits. CONCLUSIONS: Based on the association signals and differential expression of nearby genes, 14 candidate loci and genes for IMF(Br), meat L* and b* values, and AbF are identified. The results provide new insight into the molecular mechanisms underlying meat quality traits in chickens.
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spelling pubmed-37077612013-07-15 The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study Sun, Yanfa Zhao, Guiping Liu, Ranran Zheng, Maiqing Hu, Yaodong Wu, Dan Zhang, Lei Li, Peng Wen, Jie BMC Genomics Research Article BACKGROUND: Meat quality is an important economic trait in chickens. To identify loci and genes associated with meat quality traits, we conducted a genome-wide association study (GWAS) of F2 populations derived from a local Chinese breed (Beijing-You chickens) and a commercial fast-growing broiler line (Cobb-Vantress). RESULTS: In the present study, 33 association signals were detected from the compressed mixed linear model (MLM) for 10 meat quality traits: dry matter in breast muscle (DM(Br)), dry matter in thigh muscle (DM(Th)), intramuscular fat content in breast muscle (IMF(Br)), meat color lightness (L*) and yellowness (b*) values, skin color L*, a* (redness) and b* values, abdominal fat weight (AbFW) and AbFW as a percentage of eviscerated weight (AbFP). Relative expressions of candidate genes identified near significant signals were compared using samples of chickens with High and Low phenotypic values. A total of 14 genes associated with IMF(Br), meat color L*, AbFW, and AbFP, were differentially expressed between the High and Low phenotypic groups. These genes are, therefore, prospective candidate genes for meat quality traits: protein tyrosine kinase (TYRO3) and microsomal glutathione S-transferase 1 (MGST1) for IMF(Br); collagen, type I, alpha 2 (COL1A2) for meat color L*; and RET proto-oncogene (RET), natriuretic peptide B (NPPB) and sterol regulatory element binding transcription factor 1 (SREBF1) for the abdominal fat (AbF) traits. CONCLUSIONS: Based on the association signals and differential expression of nearby genes, 14 candidate loci and genes for IMF(Br), meat L* and b* values, and AbF are identified. The results provide new insight into the molecular mechanisms underlying meat quality traits in chickens. BioMed Central 2013-07-08 /pmc/articles/PMC3707761/ /pubmed/23834466 http://dx.doi.org/10.1186/1471-2164-14-458 Text en Copyright © 2013 Sun et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Yanfa
Zhao, Guiping
Liu, Ranran
Zheng, Maiqing
Hu, Yaodong
Wu, Dan
Zhang, Lei
Li, Peng
Wen, Jie
The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title_full The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title_fullStr The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title_full_unstemmed The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title_short The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
title_sort identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707761/
https://www.ncbi.nlm.nih.gov/pubmed/23834466
http://dx.doi.org/10.1186/1471-2164-14-458
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