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Specific structure and unique function define the hemicentin
Hemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate tissues and organs. Highly conserved hemicentin sequences across species indicate this ge...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707829/ https://www.ncbi.nlm.nih.gov/pubmed/23803222 http://dx.doi.org/10.1186/2045-3701-3-27 |
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author | Xu, Xuehong Xu, MengMeng Zhou, Xin Jones, Odell B Moharomd, Edward Pan, Yuexin Yan, Guifang Anthony, Donald D Isaacs, Williams B |
author_facet | Xu, Xuehong Xu, MengMeng Zhou, Xin Jones, Odell B Moharomd, Edward Pan, Yuexin Yan, Guifang Anthony, Donald D Isaacs, Williams B |
author_sort | Xu, Xuehong |
collection | PubMed |
description | Hemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate tissues and organs. Highly conserved hemicentin sequences across species indicate this gene’s ancient evolutionary roots and functional importance. In mouse, hemicentin is liberally distributed on the cell surface of many cell types, including epithelial cells, endothelial cells of the eye, lung, and uterus, and trophectodermal cells of blastocyst. Recent discoveries have uncovered yet another vital purpose of hemicentin 1. The protein also serves a unique function in mitotic cytokinesis, during which this extracellular matrix protein plays a key role in cleavage furrow maturation. Though understanding of hemicentin function has improved through new discoveries, much about this protein remains mysterious. |
format | Online Article Text |
id | pubmed-3707829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37078292013-07-11 Specific structure and unique function define the hemicentin Xu, Xuehong Xu, MengMeng Zhou, Xin Jones, Odell B Moharomd, Edward Pan, Yuexin Yan, Guifang Anthony, Donald D Isaacs, Williams B Cell Biosci Review Hemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate tissues and organs. Highly conserved hemicentin sequences across species indicate this gene’s ancient evolutionary roots and functional importance. In mouse, hemicentin is liberally distributed on the cell surface of many cell types, including epithelial cells, endothelial cells of the eye, lung, and uterus, and trophectodermal cells of blastocyst. Recent discoveries have uncovered yet another vital purpose of hemicentin 1. The protein also serves a unique function in mitotic cytokinesis, during which this extracellular matrix protein plays a key role in cleavage furrow maturation. Though understanding of hemicentin function has improved through new discoveries, much about this protein remains mysterious. BioMed Central 2013-06-26 /pmc/articles/PMC3707829/ /pubmed/23803222 http://dx.doi.org/10.1186/2045-3701-3-27 Text en Copyright © 2013 Xu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Xu, Xuehong Xu, MengMeng Zhou, Xin Jones, Odell B Moharomd, Edward Pan, Yuexin Yan, Guifang Anthony, Donald D Isaacs, Williams B Specific structure and unique function define the hemicentin |
title | Specific structure and unique function define the hemicentin |
title_full | Specific structure and unique function define the hemicentin |
title_fullStr | Specific structure and unique function define the hemicentin |
title_full_unstemmed | Specific structure and unique function define the hemicentin |
title_short | Specific structure and unique function define the hemicentin |
title_sort | specific structure and unique function define the hemicentin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707829/ https://www.ncbi.nlm.nih.gov/pubmed/23803222 http://dx.doi.org/10.1186/2045-3701-3-27 |
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