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Phosphatidylinositol 4,5-Bisphosphate Decreases the Concentration of Ca(2+), Phosphatidylserine and Diacylglycerol Required for Protein Kinase C α to Reach Maximum Activity
The C2 domain of PKCα possesses two different binding sites, one for Ca(2+) and phosphatidylserine and a second one that binds PIP(2) with very high affinity. The enzymatic activity of PKCα was studied by activating it with large unilamellar lipid vesicles, varying the concentration of Ca(2+) and th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707892/ https://www.ncbi.nlm.nih.gov/pubmed/23874859 http://dx.doi.org/10.1371/journal.pone.0069041 |