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Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implanta...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708148/ https://www.ncbi.nlm.nih.gov/pubmed/23878549 http://dx.doi.org/10.5114/jcb.2013.36174 |
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author | Salembier, Carl Rijnders, Alex Henry, Ann Niehoff, Peter André Siebert, Frank Hoskin, Peter |
author_facet | Salembier, Carl Rijnders, Alex Henry, Ann Niehoff, Peter André Siebert, Frank Hoskin, Peter |
author_sort | Salembier, Carl |
collection | PubMed |
description | PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implantation after prior prostate transurethral resection (TURP). MATERIAL AND METHODS: A reference transrectal ultrasound image set of the prostate gland from a patient who had undergone TURP was used. Contouring of the prostate, clinical target volume and organs at risk was performed by the coordinating center. Goals and constraints regarding the dosimetry were defined. RESULTS: Seventeen of twenty-five centers invited to participate were able to import the Digital Imaging and Communications in Medicine-images into their planning computer and plan the implant using the defined guidelines. All centers were able to plan treatment, and achieve the recommended objectives and constraints. However, sector analysis has shown a risk of under-dosage in the anterior part of the prostate. CONCLUSIONS: Correct pre-implantation planning with adherence to protocol guidelines and in compliance with defined dosimetric constraints seems feasible in a post-TURP setting, at least on a theoretical basis. A prospective study evaluating the outcome of prostate brachytherapy performed after TURP can therefore be undertaken with an expectation of a correct dosimetry in the multicenter setting. |
format | Online Article Text |
id | pubmed-3708148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-37081482013-07-22 Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection Salembier, Carl Rijnders, Alex Henry, Ann Niehoff, Peter André Siebert, Frank Hoskin, Peter J Contemp Brachytherapy Original Paper PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implantation after prior prostate transurethral resection (TURP). MATERIAL AND METHODS: A reference transrectal ultrasound image set of the prostate gland from a patient who had undergone TURP was used. Contouring of the prostate, clinical target volume and organs at risk was performed by the coordinating center. Goals and constraints regarding the dosimetry were defined. RESULTS: Seventeen of twenty-five centers invited to participate were able to import the Digital Imaging and Communications in Medicine-images into their planning computer and plan the implant using the defined guidelines. All centers were able to plan treatment, and achieve the recommended objectives and constraints. However, sector analysis has shown a risk of under-dosage in the anterior part of the prostate. CONCLUSIONS: Correct pre-implantation planning with adherence to protocol guidelines and in compliance with defined dosimetric constraints seems feasible in a post-TURP setting, at least on a theoretical basis. A prospective study evaluating the outcome of prostate brachytherapy performed after TURP can therefore be undertaken with an expectation of a correct dosimetry in the multicenter setting. Termedia Publishing House 2013-06-28 2013-06 /pmc/articles/PMC3708148/ /pubmed/23878549 http://dx.doi.org/10.5114/jcb.2013.36174 Text en Copyright © 2013 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Salembier, Carl Rijnders, Alex Henry, Ann Niehoff, Peter André Siebert, Frank Hoskin, Peter Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title | Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title_full | Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title_fullStr | Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title_full_unstemmed | Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title_short | Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection |
title_sort | prospective multi-center dosimetry study of low-dose iodine-125 prostate brachytherapy performed after transurethral resection |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708148/ https://www.ncbi.nlm.nih.gov/pubmed/23878549 http://dx.doi.org/10.5114/jcb.2013.36174 |
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