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Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection

PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implanta...

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Autores principales: Salembier, Carl, Rijnders, Alex, Henry, Ann, Niehoff, Peter, André Siebert, Frank, Hoskin, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708148/
https://www.ncbi.nlm.nih.gov/pubmed/23878549
http://dx.doi.org/10.5114/jcb.2013.36174
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author Salembier, Carl
Rijnders, Alex
Henry, Ann
Niehoff, Peter
André Siebert, Frank
Hoskin, Peter
author_facet Salembier, Carl
Rijnders, Alex
Henry, Ann
Niehoff, Peter
André Siebert, Frank
Hoskin, Peter
author_sort Salembier, Carl
collection PubMed
description PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implantation after prior prostate transurethral resection (TURP). MATERIAL AND METHODS: A reference transrectal ultrasound image set of the prostate gland from a patient who had undergone TURP was used. Contouring of the prostate, clinical target volume and organs at risk was performed by the coordinating center. Goals and constraints regarding the dosimetry were defined. RESULTS: Seventeen of twenty-five centers invited to participate were able to import the Digital Imaging and Communications in Medicine-images into their planning computer and plan the implant using the defined guidelines. All centers were able to plan treatment, and achieve the recommended objectives and constraints. However, sector analysis has shown a risk of under-dosage in the anterior part of the prostate. CONCLUSIONS: Correct pre-implantation planning with adherence to protocol guidelines and in compliance with defined dosimetric constraints seems feasible in a post-TURP setting, at least on a theoretical basis. A prospective study evaluating the outcome of prostate brachytherapy performed after TURP can therefore be undertaken with an expectation of a correct dosimetry in the multicenter setting.
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spelling pubmed-37081482013-07-22 Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection Salembier, Carl Rijnders, Alex Henry, Ann Niehoff, Peter André Siebert, Frank Hoskin, Peter J Contemp Brachytherapy Original Paper PURPOSE: To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implantation after prior prostate transurethral resection (TURP). MATERIAL AND METHODS: A reference transrectal ultrasound image set of the prostate gland from a patient who had undergone TURP was used. Contouring of the prostate, clinical target volume and organs at risk was performed by the coordinating center. Goals and constraints regarding the dosimetry were defined. RESULTS: Seventeen of twenty-five centers invited to participate were able to import the Digital Imaging and Communications in Medicine-images into their planning computer and plan the implant using the defined guidelines. All centers were able to plan treatment, and achieve the recommended objectives and constraints. However, sector analysis has shown a risk of under-dosage in the anterior part of the prostate. CONCLUSIONS: Correct pre-implantation planning with adherence to protocol guidelines and in compliance with defined dosimetric constraints seems feasible in a post-TURP setting, at least on a theoretical basis. A prospective study evaluating the outcome of prostate brachytherapy performed after TURP can therefore be undertaken with an expectation of a correct dosimetry in the multicenter setting. Termedia Publishing House 2013-06-28 2013-06 /pmc/articles/PMC3708148/ /pubmed/23878549 http://dx.doi.org/10.5114/jcb.2013.36174 Text en Copyright © 2013 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Salembier, Carl
Rijnders, Alex
Henry, Ann
Niehoff, Peter
André Siebert, Frank
Hoskin, Peter
Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title_full Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title_fullStr Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title_full_unstemmed Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title_short Prospective multi-center dosimetry study of low-dose Iodine-125 prostate brachytherapy performed after transurethral resection
title_sort prospective multi-center dosimetry study of low-dose iodine-125 prostate brachytherapy performed after transurethral resection
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708148/
https://www.ncbi.nlm.nih.gov/pubmed/23878549
http://dx.doi.org/10.5114/jcb.2013.36174
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