Calcineurin A versus NS5A-TP2/HD Domain Containing 2: A Case Study of Site-directed Low-frequency Random Mutagenesis for Dissecting Target Specificity of Peptide Aptamers

We previously identified a peptide aptamer (named R5G42) via functional selection for its capacity to slow cell proliferation. A yeast two-hybrid screen of human cDNA libraries, using R5G42 as “bait,” allowed the identification of two binding proteins with very different functions: calcineurin A (Cn...

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Detalles Bibliográficos
Autores principales: Dibenedetto, Silvia, Cluet, David, Stebe, Pierre-Nicolas, Baumle, Véronique, Léault, Jérémie, Terreux, Raphaël, Bickle, Marc, Chassey, Benoit D. E., Mikaelian, Ivan, Colas, Pierre, Spichty, Martin, Zoli, Michele, Rudkin, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708177/
https://www.ncbi.nlm.nih.gov/pubmed/23579184
http://dx.doi.org/10.1074/mcp.M112.024612

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