Cargando…
Misleading Elevation of Troponin T caused by Polymyositis
BACKGROUND: Elevations of cardiac enzymes are commonly used to indicate myocardial ischemia, but they can be elevated due to other conditions. Different forms of Troponin (cTnT, sTnT, cTnI), can cause cross-reactivity in the Troponin T assay, leading to false positives. This report describes a patie...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Master Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708267/ https://www.ncbi.nlm.nih.gov/pubmed/23847461 |
_version_ | 1782276592591962112 |
---|---|
author | Dhir, Teena Jiang, Ning |
author_facet | Dhir, Teena Jiang, Ning |
author_sort | Dhir, Teena |
collection | PubMed |
description | BACKGROUND: Elevations of cardiac enzymes are commonly used to indicate myocardial ischemia, but they can be elevated due to other conditions. Different forms of Troponin (cTnT, sTnT, cTnI), can cause cross-reactivity in the Troponin T assay, leading to false positives. This report describes a patient with polymyositis who had elevated Troponin T, but no cardiac abnormalities. The purpose is to show that Troponin T, which is believed to be solely from cardiac muscle breakdown, can be seen in inflammatory muscle disease, so Troponin I should be used instead. DESCRIPTION: This is a case report of a 70-year-old woman with a history of diabetes, hypertension, gout and polymyositis, who presented with one-day history of lightheadedness and abdominal pain. To rule out myocardial ischemia, cardiac enzyme testing was ordered which showed elevated CK, CK-MB, and Troponin T. A full cardiac workup was performed which showed no signs of ischemia. Troponin I was <0.05 ng/mL, (normal). DISCUSSION: In inflammatory myositis, there are elevations in many cardiac markers due to non-cardiac causes, which could be related to muscle regeneration and gene expression. This is not seen certain isoforms of Troponin I, specifically cardiac Troponin I. CONCLUSION: In patients with history of diabetes and other comorbidities, silent myocardial ischemias should be ruled out. Non-cardiac elevations in Troponin T can be seen in patients with inflammatory, so Troponin I should be ordered to get an accurate interpretation. Patients with inflammatory myopathies can have elevations in CK, CK-MB, and Troponin T, but not Troponin I. |
format | Online Article Text |
id | pubmed-3708267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Master Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37082672013-07-11 Misleading Elevation of Troponin T caused by Polymyositis Dhir, Teena Jiang, Ning Int J Biomed Sci Case Report BACKGROUND: Elevations of cardiac enzymes are commonly used to indicate myocardial ischemia, but they can be elevated due to other conditions. Different forms of Troponin (cTnT, sTnT, cTnI), can cause cross-reactivity in the Troponin T assay, leading to false positives. This report describes a patient with polymyositis who had elevated Troponin T, but no cardiac abnormalities. The purpose is to show that Troponin T, which is believed to be solely from cardiac muscle breakdown, can be seen in inflammatory muscle disease, so Troponin I should be used instead. DESCRIPTION: This is a case report of a 70-year-old woman with a history of diabetes, hypertension, gout and polymyositis, who presented with one-day history of lightheadedness and abdominal pain. To rule out myocardial ischemia, cardiac enzyme testing was ordered which showed elevated CK, CK-MB, and Troponin T. A full cardiac workup was performed which showed no signs of ischemia. Troponin I was <0.05 ng/mL, (normal). DISCUSSION: In inflammatory myositis, there are elevations in many cardiac markers due to non-cardiac causes, which could be related to muscle regeneration and gene expression. This is not seen certain isoforms of Troponin I, specifically cardiac Troponin I. CONCLUSION: In patients with history of diabetes and other comorbidities, silent myocardial ischemias should be ruled out. Non-cardiac elevations in Troponin T can be seen in patients with inflammatory, so Troponin I should be ordered to get an accurate interpretation. Patients with inflammatory myopathies can have elevations in CK, CK-MB, and Troponin T, but not Troponin I. Master Publishing Group 2013-06 /pmc/articles/PMC3708267/ /pubmed/23847461 Text en © Teena Dhir et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Dhir, Teena Jiang, Ning Misleading Elevation of Troponin T caused by Polymyositis |
title | Misleading Elevation of Troponin T caused by Polymyositis |
title_full | Misleading Elevation of Troponin T caused by Polymyositis |
title_fullStr | Misleading Elevation of Troponin T caused by Polymyositis |
title_full_unstemmed | Misleading Elevation of Troponin T caused by Polymyositis |
title_short | Misleading Elevation of Troponin T caused by Polymyositis |
title_sort | misleading elevation of troponin t caused by polymyositis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708267/ https://www.ncbi.nlm.nih.gov/pubmed/23847461 |
work_keys_str_mv | AT dhirteena misleadingelevationoftroponintcausedbypolymyositis AT jiangning misleadingelevationoftroponintcausedbypolymyositis |