Cargando…

CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients

Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. Rheumatic heart disease (RHD), the major sequel of RF, leads to chronic inflammation of the myocardium and valvular tissue. T cells are the main popul...

Descripción completa

Detalles Bibliográficos
Autores principales: Faé, Kellen C., Palacios, Selma A., Nogueira, Luciana G., Oshiro, Sandra E., Demarchi, Léa M. F., Bilate, Angelina M. B., Pomerantzeff, Pablo M. A., Brandão, Carlos, Thomaz, Petronio G., dos Reis, Maxwell, Sampaio, Roney, Tanaka, Ana C., Cunha-Neto, Edecio, Kalil, Jorge, Guilherme, Luiza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708284/
https://www.ncbi.nlm.nih.gov/pubmed/23417848
http://dx.doi.org/10.1007/s10753-013-9606-2
_version_ 1782276596609056768
author Faé, Kellen C.
Palacios, Selma A.
Nogueira, Luciana G.
Oshiro, Sandra E.
Demarchi, Léa M. F.
Bilate, Angelina M. B.
Pomerantzeff, Pablo M. A.
Brandão, Carlos
Thomaz, Petronio G.
dos Reis, Maxwell
Sampaio, Roney
Tanaka, Ana C.
Cunha-Neto, Edecio
Kalil, Jorge
Guilherme, Luiza
author_facet Faé, Kellen C.
Palacios, Selma A.
Nogueira, Luciana G.
Oshiro, Sandra E.
Demarchi, Léa M. F.
Bilate, Angelina M. B.
Pomerantzeff, Pablo M. A.
Brandão, Carlos
Thomaz, Petronio G.
dos Reis, Maxwell
Sampaio, Roney
Tanaka, Ana C.
Cunha-Neto, Edecio
Kalil, Jorge
Guilherme, Luiza
author_sort Faé, Kellen C.
collection PubMed
description Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. Rheumatic heart disease (RHD), the major sequel of RF, leads to chronic inflammation of the myocardium and valvular tissue. T cells are the main population infiltrating cardiac lesions; however, the chemokines that orchestrate their recruitment are not clearly defined. Here, we investigated the expression of chemokines and chemokine receptors in cardiac tissue biopsies obtained from chronic RHD patients. Our results showed that CCL3/MIP1α gene expression was upregulated in myocardium while CCL1/I-309 and CXCL9/Mig were highly expressed in valvular tissue. Auto-reactive T cells that infiltrate valvular lesions presented a memory phenotype (CD4(+)CD45RO(+)) and migrate mainly toward CXCL9/Mig gradient. Collectively, our results show that a diverse milieu of chemokines is expressed in myocardium and valvular tissue lesions and emphasize the role of CXCL9/Mig in mediating T cell recruitment to the site of inflammation in the heart.
format Online
Article
Text
id pubmed-3708284
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-37082842013-07-12 CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients Faé, Kellen C. Palacios, Selma A. Nogueira, Luciana G. Oshiro, Sandra E. Demarchi, Léa M. F. Bilate, Angelina M. B. Pomerantzeff, Pablo M. A. Brandão, Carlos Thomaz, Petronio G. dos Reis, Maxwell Sampaio, Roney Tanaka, Ana C. Cunha-Neto, Edecio Kalil, Jorge Guilherme, Luiza Inflammation Article Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. Rheumatic heart disease (RHD), the major sequel of RF, leads to chronic inflammation of the myocardium and valvular tissue. T cells are the main population infiltrating cardiac lesions; however, the chemokines that orchestrate their recruitment are not clearly defined. Here, we investigated the expression of chemokines and chemokine receptors in cardiac tissue biopsies obtained from chronic RHD patients. Our results showed that CCL3/MIP1α gene expression was upregulated in myocardium while CCL1/I-309 and CXCL9/Mig were highly expressed in valvular tissue. Auto-reactive T cells that infiltrate valvular lesions presented a memory phenotype (CD4(+)CD45RO(+)) and migrate mainly toward CXCL9/Mig gradient. Collectively, our results show that a diverse milieu of chemokines is expressed in myocardium and valvular tissue lesions and emphasize the role of CXCL9/Mig in mediating T cell recruitment to the site of inflammation in the heart. Springer US 2013-02-17 2013 /pmc/articles/PMC3708284/ /pubmed/23417848 http://dx.doi.org/10.1007/s10753-013-9606-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Faé, Kellen C.
Palacios, Selma A.
Nogueira, Luciana G.
Oshiro, Sandra E.
Demarchi, Léa M. F.
Bilate, Angelina M. B.
Pomerantzeff, Pablo M. A.
Brandão, Carlos
Thomaz, Petronio G.
dos Reis, Maxwell
Sampaio, Roney
Tanaka, Ana C.
Cunha-Neto, Edecio
Kalil, Jorge
Guilherme, Luiza
CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title_full CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title_fullStr CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title_full_unstemmed CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title_short CXCL9/Mig Mediates T cells Recruitment to Valvular Tissue Lesions of Chronic Rheumatic Heart Disease Patients
title_sort cxcl9/mig mediates t cells recruitment to valvular tissue lesions of chronic rheumatic heart disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708284/
https://www.ncbi.nlm.nih.gov/pubmed/23417848
http://dx.doi.org/10.1007/s10753-013-9606-2
work_keys_str_mv AT faekellenc cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT palaciosselmaa cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT nogueiralucianag cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT oshirosandrae cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT demarchileamf cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT bilateangelinamb cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT pomerantzeffpabloma cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT brandaocarlos cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT thomazpetroniog cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT dosreismaxwell cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT sampaioroney cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT tanakaanac cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT cunhanetoedecio cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT kaliljorge cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients
AT guilhermeluiza cxcl9migmediatestcellsrecruitmenttovalvulartissuelesionsofchronicrheumaticheartdiseasepatients