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Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/M...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708334/ https://www.ncbi.nlm.nih.gov/pubmed/23698160 http://dx.doi.org/10.3390/nu5051531 |
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author | Zappacosta, Bruno Mastroiacovo, Pierpaolo Persichilli, Silvia Pounis, George Ruggeri, Stefania Minucci, Angelo Carnovale, Emilia Andria, Generoso Ricci, Roberta Scala, Iris Genovese, Orazio Turrini, Aida Mistura, Lorenza Giardina, Bruno Iacoviello, Licia |
author_facet | Zappacosta, Bruno Mastroiacovo, Pierpaolo Persichilli, Silvia Pounis, George Ruggeri, Stefania Minucci, Angelo Carnovale, Emilia Andria, Generoso Ricci, Roberta Scala, Iris Genovese, Orazio Turrini, Aida Mistura, Lorenza Giardina, Bruno Iacoviello, Licia |
author_sort | Zappacosta, Bruno |
collection | PubMed |
description | Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% (p < 0.002), 19.4% (p < 0.001) and 21.9% (p < 0.001), as compared to baseline levels and significantly as compared to placebo (p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations. |
format | Online Article Text |
id | pubmed-3708334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37083342013-07-11 Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia Zappacosta, Bruno Mastroiacovo, Pierpaolo Persichilli, Silvia Pounis, George Ruggeri, Stefania Minucci, Angelo Carnovale, Emilia Andria, Generoso Ricci, Roberta Scala, Iris Genovese, Orazio Turrini, Aida Mistura, Lorenza Giardina, Bruno Iacoviello, Licia Nutrients Article Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% (p < 0.002), 19.4% (p < 0.001) and 21.9% (p < 0.001), as compared to baseline levels and significantly as compared to placebo (p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations. MDPI 2013-05-08 /pmc/articles/PMC3708334/ /pubmed/23698160 http://dx.doi.org/10.3390/nu5051531 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Zappacosta, Bruno Mastroiacovo, Pierpaolo Persichilli, Silvia Pounis, George Ruggeri, Stefania Minucci, Angelo Carnovale, Emilia Andria, Generoso Ricci, Roberta Scala, Iris Genovese, Orazio Turrini, Aida Mistura, Lorenza Giardina, Bruno Iacoviello, Licia Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title | Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title_full | Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title_fullStr | Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title_full_unstemmed | Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title_short | Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia |
title_sort | homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708334/ https://www.ncbi.nlm.nih.gov/pubmed/23698160 http://dx.doi.org/10.3390/nu5051531 |
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