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Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia

Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/M...

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Autores principales: Zappacosta, Bruno, Mastroiacovo, Pierpaolo, Persichilli, Silvia, Pounis, George, Ruggeri, Stefania, Minucci, Angelo, Carnovale, Emilia, Andria, Generoso, Ricci, Roberta, Scala, Iris, Genovese, Orazio, Turrini, Aida, Mistura, Lorenza, Giardina, Bruno, Iacoviello, Licia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708334/
https://www.ncbi.nlm.nih.gov/pubmed/23698160
http://dx.doi.org/10.3390/nu5051531
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author Zappacosta, Bruno
Mastroiacovo, Pierpaolo
Persichilli, Silvia
Pounis, George
Ruggeri, Stefania
Minucci, Angelo
Carnovale, Emilia
Andria, Generoso
Ricci, Roberta
Scala, Iris
Genovese, Orazio
Turrini, Aida
Mistura, Lorenza
Giardina, Bruno
Iacoviello, Licia
author_facet Zappacosta, Bruno
Mastroiacovo, Pierpaolo
Persichilli, Silvia
Pounis, George
Ruggeri, Stefania
Minucci, Angelo
Carnovale, Emilia
Andria, Generoso
Ricci, Roberta
Scala, Iris
Genovese, Orazio
Turrini, Aida
Mistura, Lorenza
Giardina, Bruno
Iacoviello, Licia
author_sort Zappacosta, Bruno
collection PubMed
description Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% (p < 0.002), 19.4% (p < 0.001) and 21.9% (p < 0.001), as compared to baseline levels and significantly as compared to placebo (p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations.
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spelling pubmed-37083342013-07-11 Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia Zappacosta, Bruno Mastroiacovo, Pierpaolo Persichilli, Silvia Pounis, George Ruggeri, Stefania Minucci, Angelo Carnovale, Emilia Andria, Generoso Ricci, Roberta Scala, Iris Genovese, Orazio Turrini, Aida Mistura, Lorenza Giardina, Bruno Iacoviello, Licia Nutrients Article Background/Objectives: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% (p < 0.002), 19.4% (p < 0.001) and 21.9% (p < 0.001), as compared to baseline levels and significantly as compared to placebo (p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations. MDPI 2013-05-08 /pmc/articles/PMC3708334/ /pubmed/23698160 http://dx.doi.org/10.3390/nu5051531 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zappacosta, Bruno
Mastroiacovo, Pierpaolo
Persichilli, Silvia
Pounis, George
Ruggeri, Stefania
Minucci, Angelo
Carnovale, Emilia
Andria, Generoso
Ricci, Roberta
Scala, Iris
Genovese, Orazio
Turrini, Aida
Mistura, Lorenza
Giardina, Bruno
Iacoviello, Licia
Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title_full Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title_fullStr Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title_full_unstemmed Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title_short Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
title_sort homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708334/
https://www.ncbi.nlm.nih.gov/pubmed/23698160
http://dx.doi.org/10.3390/nu5051531
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