Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty aci...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaggini, Melania, Morelli, Mariangela, Buzzigoli, Emma, DeFronzo, Ralph A., Bugianesi, Elisabetta, Gastaldelli, Amalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708335/
https://www.ncbi.nlm.nih.gov/pubmed/23666091
http://dx.doi.org/10.3390/nu5051544
_version_ 1782276602782023680
author Gaggini, Melania
Morelli, Mariangela
Buzzigoli, Emma
DeFronzo, Ralph A.
Bugianesi, Elisabetta
Gastaldelli, Amalia
author_facet Gaggini, Melania
Morelli, Mariangela
Buzzigoli, Emma
DeFronzo, Ralph A.
Bugianesi, Elisabetta
Gastaldelli, Amalia
author_sort Gaggini, Melania
collection PubMed
description Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.
format Online
Article
Text
id pubmed-3708335
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-37083352013-07-11 Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease Gaggini, Melania Morelli, Mariangela Buzzigoli, Emma DeFronzo, Ralph A. Bugianesi, Elisabetta Gastaldelli, Amalia Nutrients Review Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease. MDPI 2013-05-10 /pmc/articles/PMC3708335/ /pubmed/23666091 http://dx.doi.org/10.3390/nu5051544 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Gaggini, Melania
Morelli, Mariangela
Buzzigoli, Emma
DeFronzo, Ralph A.
Bugianesi, Elisabetta
Gastaldelli, Amalia
Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title_full Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title_fullStr Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title_full_unstemmed Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title_short Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
title_sort non-alcoholic fatty liver disease (nafld) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708335/
https://www.ncbi.nlm.nih.gov/pubmed/23666091
http://dx.doi.org/10.3390/nu5051544
work_keys_str_mv AT gagginimelania nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease
AT morellimariangela nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease
AT buzzigoliemma nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease
AT defronzoralpha nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease
AT bugianesielisabetta nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease
AT gastaldelliamalia nonalcoholicfattyliverdiseasenafldanditsconnectionwithinsulinresistancedyslipidemiaatherosclerosisandcoronaryheartdisease

Ejemplares similares