A Scan for Human-Specific Relaxation of Negative Selection Reveals Unexpected Polymorphism in Proteasome Genes

Environmental or genomic changes during evolution can relax negative selection pressure on specific loci, permitting high frequency polymorphisms at previously conserved sites. Here, we jointly analyze population genomic and comparative genomic data to search for functional processes showing relaxed...

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Detalles Bibliográficos
Autores principales: Somel, Mehmet, Wilson Sayres, Melissa A., Jordan, Gregory, Huerta-Sanchez, Emilia, Fumagalli, Matteo, Ferrer-Admetlla, Anna, Nielsen, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708504/
https://www.ncbi.nlm.nih.gov/pubmed/23699470
http://dx.doi.org/10.1093/molbev/mst098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708504/
https://www.ncbi.nlm.nih.gov/pubmed/23699470
http://dx.doi.org/10.1093/molbev/mst098

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