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Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme
The relationship between genotype and phenotype is often described as an adaptive fitness landscape. In this study, we used a combination of recombination, in vitro selection, and comparative sequence analysis to characterize the fitness landscape of a previously isolated kinase ribozyme. Point muta...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708531/ https://www.ncbi.nlm.nih.gov/pubmed/23798664 http://dx.doi.org/10.1261/rna.037572.112 |