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Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study
BACKGROUND: In addition to lung cancers, tuberculosis infections have been associated with increased risk of non-pulmonary malignancies in case reports. Our population-based study employed standardized incidence ratios (SIRs) to systemically survey non-pulmonary cancer risks after tuberculosis infec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708573/ https://www.ncbi.nlm.nih.gov/pubmed/23652313 http://dx.doi.org/10.1038/bjc.2013.220 |
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author | Kuo, S-C Hu, Y-W Liu, C-J Lee, Y-T Chen, Y-T Chen, T-L Chen, T-J Fung, C-P |
author_facet | Kuo, S-C Hu, Y-W Liu, C-J Lee, Y-T Chen, Y-T Chen, T-L Chen, T-J Fung, C-P |
author_sort | Kuo, S-C |
collection | PubMed |
description | BACKGROUND: In addition to lung cancers, tuberculosis infections have been associated with increased risk of non-pulmonary malignancies in case reports. Our population-based study employed standardized incidence ratios (SIRs) to systemically survey non-pulmonary cancer risks after tuberculosis infections. METHODS: Data of patients who had newly diagnosed tuberculosis, were aged 20 years or older, and had no prior cancer or tuberculosis were sampled from the Taiwan National Health Insurance database between 2000 and 2010. SIRs compared cancer incidence in patients with tuberculosis infections to the general population. SIRs of specific cancers were further analyzed with respect to gender and time after tuberculosis infections. RESULTS: After a follow-up period of 28 866 person–years, 530 tuberculosis cases developed cancers compared with 256 cases in the general populations (2.07, 95% confidence interval (CI), 1.90–2.26). The SIR of non-pulmonary malignancies was also increased (1.71, 95% CI, 1.54–1.90). For males, SIRs were increased within 1 year after tuberculosis diagnosis for the following cancers: head and neck, esophageal, colorectal, liver, lung, melanomas, and Hodgkin's disease. SIRs were increased for liver, biliary, lung, and bladder cancers beyond the first year after tuberculosis diagnosis. For females, SIRs were increased for leukemia, esophageal, and lung cancers within the first year, and only for leukemia beyond 1 year post diagnosis. CONCLUSION: Having found increased risks of several cancers that differ with gender and time after tuberculosis diagnosis, physicians may consider these factors in patients following tuberculosis diagnosis. |
format | Online Article Text |
id | pubmed-3708573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37085732014-07-09 Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study Kuo, S-C Hu, Y-W Liu, C-J Lee, Y-T Chen, Y-T Chen, T-L Chen, T-J Fung, C-P Br J Cancer Epidemiology BACKGROUND: In addition to lung cancers, tuberculosis infections have been associated with increased risk of non-pulmonary malignancies in case reports. Our population-based study employed standardized incidence ratios (SIRs) to systemically survey non-pulmonary cancer risks after tuberculosis infections. METHODS: Data of patients who had newly diagnosed tuberculosis, were aged 20 years or older, and had no prior cancer or tuberculosis were sampled from the Taiwan National Health Insurance database between 2000 and 2010. SIRs compared cancer incidence in patients with tuberculosis infections to the general population. SIRs of specific cancers were further analyzed with respect to gender and time after tuberculosis infections. RESULTS: After a follow-up period of 28 866 person–years, 530 tuberculosis cases developed cancers compared with 256 cases in the general populations (2.07, 95% confidence interval (CI), 1.90–2.26). The SIR of non-pulmonary malignancies was also increased (1.71, 95% CI, 1.54–1.90). For males, SIRs were increased within 1 year after tuberculosis diagnosis for the following cancers: head and neck, esophageal, colorectal, liver, lung, melanomas, and Hodgkin's disease. SIRs were increased for liver, biliary, lung, and bladder cancers beyond the first year after tuberculosis diagnosis. For females, SIRs were increased for leukemia, esophageal, and lung cancers within the first year, and only for leukemia beyond 1 year post diagnosis. CONCLUSION: Having found increased risks of several cancers that differ with gender and time after tuberculosis diagnosis, physicians may consider these factors in patients following tuberculosis diagnosis. Nature Publishing Group 2013-07-09 2013-05-07 /pmc/articles/PMC3708573/ /pubmed/23652313 http://dx.doi.org/10.1038/bjc.2013.220 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Kuo, S-C Hu, Y-W Liu, C-J Lee, Y-T Chen, Y-T Chen, T-L Chen, T-J Fung, C-P Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title | Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title_full | Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title_fullStr | Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title_full_unstemmed | Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title_short | Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
title_sort | association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708573/ https://www.ncbi.nlm.nih.gov/pubmed/23652313 http://dx.doi.org/10.1038/bjc.2013.220 |
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