NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology

Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain...

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Detalles Bibliográficos
Autores principales: Vahl, J. Christoph, Heger, Klaus, Knies, Nathalie, Hein, Marco Y., Boon, Louis, Yagita, Hideo, Polic, Bojan, Schmidt-Supprian, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708704/
https://www.ncbi.nlm.nih.gov/pubmed/23853545
http://dx.doi.org/10.1371/journal.pbio.1001589

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