The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts

Self-amplification of phosphoinositide 3-kinase (PI3K) signaling is believed to regulate asymmetric membrane extension and cell migration, but the molecular organization of the underlying feedback circuit is elusive. Here we use an inducible approach to synthetically activate PI3K and interrogate th...

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Detalles Bibliográficos
Autores principales: Thevathasan, Jervis Vermal, Tan, Elisabeth, Zheng, Hui, Lin, Yu-Chun, Li, Yang, Inoue, Takanari, Fivaz, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708728/
https://www.ncbi.nlm.nih.gov/pubmed/23676667
http://dx.doi.org/10.1091/mbc.E12-12-0905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708728/
https://www.ncbi.nlm.nih.gov/pubmed/23676667
http://dx.doi.org/10.1091/mbc.E12-12-0905

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