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Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction
BACKGROUND: In patients presenting with ST-elevation myocardial infarction (STEMI), we investigated the relation of left atrial (LA) deformational parameters evaluated by two-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and B-type...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708795/ https://www.ncbi.nlm.nih.gov/pubmed/23829445 http://dx.doi.org/10.1186/1476-7120-11-24 |
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author | Dogan, Cem Ozdemir, Nihal Hatipoglu, Suzan Bakal, Ruken Bengi Omaygenc, Mehmet Onur Dindar, Baris Candan, Ozkan Emiroglu, Mehmet Yunus Kaymaz, Cihangir |
author_facet | Dogan, Cem Ozdemir, Nihal Hatipoglu, Suzan Bakal, Ruken Bengi Omaygenc, Mehmet Onur Dindar, Baris Candan, Ozkan Emiroglu, Mehmet Yunus Kaymaz, Cihangir |
author_sort | Dogan, Cem |
collection | PubMed |
description | BACKGROUND: In patients presenting with ST-elevation myocardial infarction (STEMI), we investigated the relation of left atrial (LA) deformational parameters evaluated by two-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and B-type natriuretic peptide (BNP) level. METHODS: Ninety STEMI patients who were treated with primary percutaneous coronary intervention (PCI) and 22 healthy control subjects were enrolled. STEMI patients had echocardiographic examination 48 hours after the PCI procedure and venous blood samples were drawn simultaneously. In addition to conventional echocardiographic parameters, LA strain curves were obtained for each patient. Average peak LA strain values during left ventricular (LV) systole (LAs-strain) were measured. RESULTS: BNP values were higher in MI patients compared to controls. Mean LAs-strain in control group was higher than MI group (30.6 ± 5.6% vs. 21.6 ± 6.6%; p = 0.001). LAs-strain had significant correlation with LVEF (r = 0.51, p = 0.001), also significant inverse correlations between LAs-strain and BNP level (r = −0.41, p = 0.001), E/Em (r = −0.30, p = 0.001), LA maximal volume (r = −0.41, p = 0.001), LA minimal volume (r = −0.50, p = 0.001) and LV end systolic volume (r = −0.37, p = 0.001) were detected. The cut off value of LAs-strain to predict BNP > 100 pg/ml was determined as 19.9% with 55.3% sensitivity and 77.2% specificity (p < 0.05 AUC:0.7). CONCLUSION: Our study showed that LAs-strain values decreased consistently with deteriorating systolic and diastolic function in STEMI patients treated with primary PCI. LA-s strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population. |
format | Online Article Text |
id | pubmed-3708795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37087952013-07-12 Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction Dogan, Cem Ozdemir, Nihal Hatipoglu, Suzan Bakal, Ruken Bengi Omaygenc, Mehmet Onur Dindar, Baris Candan, Ozkan Emiroglu, Mehmet Yunus Kaymaz, Cihangir Cardiovasc Ultrasound Research BACKGROUND: In patients presenting with ST-elevation myocardial infarction (STEMI), we investigated the relation of left atrial (LA) deformational parameters evaluated by two-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and B-type natriuretic peptide (BNP) level. METHODS: Ninety STEMI patients who were treated with primary percutaneous coronary intervention (PCI) and 22 healthy control subjects were enrolled. STEMI patients had echocardiographic examination 48 hours after the PCI procedure and venous blood samples were drawn simultaneously. In addition to conventional echocardiographic parameters, LA strain curves were obtained for each patient. Average peak LA strain values during left ventricular (LV) systole (LAs-strain) were measured. RESULTS: BNP values were higher in MI patients compared to controls. Mean LAs-strain in control group was higher than MI group (30.6 ± 5.6% vs. 21.6 ± 6.6%; p = 0.001). LAs-strain had significant correlation with LVEF (r = 0.51, p = 0.001), also significant inverse correlations between LAs-strain and BNP level (r = −0.41, p = 0.001), E/Em (r = −0.30, p = 0.001), LA maximal volume (r = −0.41, p = 0.001), LA minimal volume (r = −0.50, p = 0.001) and LV end systolic volume (r = −0.37, p = 0.001) were detected. The cut off value of LAs-strain to predict BNP > 100 pg/ml was determined as 19.9% with 55.3% sensitivity and 77.2% specificity (p < 0.05 AUC:0.7). CONCLUSION: Our study showed that LAs-strain values decreased consistently with deteriorating systolic and diastolic function in STEMI patients treated with primary PCI. LA-s strain measurements may be helpful as a complimentary method to evaluate diastolic function in this patient population. BioMed Central 2013-07-05 /pmc/articles/PMC3708795/ /pubmed/23829445 http://dx.doi.org/10.1186/1476-7120-11-24 Text en Copyright © 2013 Dogan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Dogan, Cem Ozdemir, Nihal Hatipoglu, Suzan Bakal, Ruken Bengi Omaygenc, Mehmet Onur Dindar, Baris Candan, Ozkan Emiroglu, Mehmet Yunus Kaymaz, Cihangir Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title | Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title_full | Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title_fullStr | Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title_full_unstemmed | Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title_short | Relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with ST-elevation myocardial infarction |
title_sort | relation of left atrial peak systolic strain with left ventricular diastolic dysfunction and brain natriuretic peptide level in patients presenting with st-elevation myocardial infarction |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708795/ https://www.ncbi.nlm.nih.gov/pubmed/23829445 http://dx.doi.org/10.1186/1476-7120-11-24 |
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