ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice

KLF3 is a Krüppel family zinc finger transcription factor with widespread tissue expression and no previously known role in heart development. In a screen for dominant mutations affecting cardiovascular function in N-ethyl-N-nitrosourea (ENU) mutagenized mice, we identified a missense mutation in th...

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Detalles Bibliográficos
Autores principales: Kelsey, Lois, Flenniken, Ann M., Qu, Dawei, Funnell, Alister P. W., Pearson, Richard, Zhou, Yu-Qing, Voronina, Irina, Berberovic, Zorana, Wood, Geoffrey, Newbigging, Susan, Weiss, Edward S., Wong, Michael, Quach, Ivan, Yeh, S. Y. Sandy, Deshwar, Ashish R., Scott, Ian C., McKerlie, Colin, Henkelman, Mark, Backx, Peter, Simpson, Jeremy, Osborne, Lucy, Rossant, Janet, Crossley, Merlin, Bruneau, Benoit, Adamson, S. Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708807/
https://www.ncbi.nlm.nih.gov/pubmed/23874215
http://dx.doi.org/10.1371/journal.pgen.1003612

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