INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo

BACKGROUND: Retroviral integrase catalyzes integration of viral DNA into the host genome. Integrase interactor (INI)1/hSNF5 is a host factor that binds to HIV-1 IN within the context of Gag-Pol and is specifically incorporated into HIV-1 virions during assembly. Previous studies have indicated that...

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Detalles Bibliográficos
Autores principales: Mathew, Sheeba, Nguyen, Minh, Wu, Xuhong, Pal, Achintya, Shah, Vaibhav B, Prasad, Vinayaka R, Aiken, Christopher, Kalpana, Ganjam V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708822/
https://www.ncbi.nlm.nih.gov/pubmed/23799881
http://dx.doi.org/10.1186/1742-4690-10-66

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