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SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice
Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and the endolymphatic sac. Slc26a4 (Δ/Δ) mice are devo...
Autores principales: | Li, Xiangming, Sanneman, Joel D., Harbidge, Donald G., Zhou, Fei, Ito, Taku, Nelson, Raoul, Picard, Nicolas, Chambrey, Régine, Eladari, Dominique, Miesner, Tracy, Griffith, Andrew J., Marcus, Daniel C., Wangemann, Philine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708829/ https://www.ncbi.nlm.nih.gov/pubmed/23874234 http://dx.doi.org/10.1371/journal.pgen.1003641 |
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