Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

BACKGROUND: The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host...

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Detalles Bibliográficos
Autores principales: Kager, Liesbeth M., Schouten, Marcel, Wiersinga, W. Joost, de Boer, J. Daan, Lattenist, Lionel C. W., Roelofs, Joris J. T. H., Meijers, Joost C. M., Levi, Marcel, Dondorp, Arjen M., Esmon, Charles T., van 't Veer, Cornelis, van der Poll, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708857/
https://www.ncbi.nlm.nih.gov/pubmed/23875041
http://dx.doi.org/10.1371/journal.pntd.0002306

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