Cargando…
Target Essentiality and Centrality Characterize Drug Side Effects
To investigate factors contributing to drug side effects, we systematically examine relationships between 4,199 side effects associated with 996 drugs and their 647 human protein targets. We find that it is the number of essential targets, not the number of total targets, that determines the side ef...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708859/ https://www.ncbi.nlm.nih.gov/pubmed/23874169 http://dx.doi.org/10.1371/journal.pcbi.1003119 |