4-1BB Signaling Activates the T Cell Factor 1 Effector/β-Catenin Pathway with Delayed Kinetics via ERK Signaling and Delayed PI3K/AKT Activation to Promote the Proliferation of CD8(+) T Cells

4-1BB (CD137), an inducible costimulatory molecule, strongly enhances the proliferation and effector function of CD8(+) T cells. Since the serine/threonine kinase, glycogen synthase kinase-3 (GSK-3), is involved in a variety of signaling pathways of cellular proliferation, migration, immune response...

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Detalles Bibliográficos
Autores principales: Lee, Do Y., Choi, Beom K., Lee, Don G., Kim, Young H., Kim, Chang H., Lee, Seung J., Kwon, Byoung S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708905/
https://www.ncbi.nlm.nih.gov/pubmed/23874982
http://dx.doi.org/10.1371/journal.pone.0069677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708905/
https://www.ncbi.nlm.nih.gov/pubmed/23874982
http://dx.doi.org/10.1371/journal.pone.0069677

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