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Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster

We describe a procedure for the conjugative transfer of phage P1-derived Artificial Chromosome (PAC) library clones containing large natural product gene clusters (≥70 kilobases) to Streptomyces coelicolor strains that have been engineered for improved heterologous production of natural products. Th...

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Detalles Bibliográficos
Autores principales:	Jones, Adam C., Gust, Bertolt, Kulik, Andreas, Heide, Lutz, Buttner, Mark J., Bibb, Mervyn J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708917/ https://www.ncbi.nlm.nih.gov/pubmed/23874942 http://dx.doi.org/10.1371/journal.pone.0069319

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