Cargando…

L-Carnitine Preserves Endothelial Function in a Lamb Model of Increased Pulmonary Blood Flow

BACKGROUND: In our model of congenital heart disease (CHD) with increased pulmonary blood flow (Shunt), we have recently shown a disruption in carnitine homeostasis, associated with mitochondrial dysfunction and decreased eNOS/Hsp90 interactions that contribute to eNOS uncoupling, increased superoxi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Shruti, Aramburo, Angela, Rafikov, Ruslan, Sun, Xutong, Kumar, Sanjiv, Oishi, Peter E., Datar, Sanjeev A., Raff, Gary, Xoinis, Kon, Kalkan, Gohkan, Fratz, Sohrab, Fineman, Jeffrey R., Black, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709010/ https://www.ncbi.nlm.nih.gov/pubmed/23628882 http://dx.doi.org/10.1038/pr.2013.71

Ejemplares similares

PPAR-γ Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow
por: Sharma, Shruti, et al.
Publicado: (2012)

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow
por: Oishi, Peter E., et al.
Publicado: (2012)

Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial Cells
por: Sharma, Shruti, et al.
Publicado: (2012)

TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis
por: Sun, Xutong, et al.
Publicado: (2020)

Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism
por: Lu, Qing, et al.
Publicado: (2015)

Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure
por: Soares, Joao Henrique N., et al.
Publicado: (2023)

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells
por: Rafikov, Ruslan, et al.
Publicado: (2015)

Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction
por: Rau, Thomas F., et al.
Publicado: (2012)

HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow
por: Boehme, Jason T., et al.
Publicado: (2021)

Does implantation of an Amplatzer septal occluder (ASO) device change ventricular contraction pattern? An MR tagging study
por: Stern, Heiko, et al.
Publicado: (2009)

Pulmonary Interstitial Glycogenosis: An Unrecognized Etiology of Persistent Pulmonary Hypertension of the Newborn in Congenital Heart Disease?
por: Radman, Monique R., et al.
Publicado: (2012)

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase()
por: Rafikov, Ruslan, et al.
Publicado: (2014)

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease
por: Zhu, Terry, et al.
Publicado: (2020)

The effect of genotype and muscle type on the physico-chemical characteristics and taurine, carnosine and L-carnitine concentration in lamb meat
por: Radzik-Rant, Aurelia, et al.
Publicado: (2020)

Comparison of L-Carnitine and L-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH
por: Acosta, Maria F., et al.
Publicado: (2020)

Endostatin, an Inhibitor of Angiogenesis, Decreases After Bidirectional Superior Cavopulmonary Anastamosis
por: Field-Ridley, Aida, et al.
Publicado: (2012)

Endothelial Nitric Oxide Synthase Deficient Mice Are Protected from Lipopolysaccharide Induced Acute Lung Injury
por: Gross, Christine M., et al.
Publicado: (2015)

Dietary Administration of L-Carnitine During the Fattening Period of Early Feed Restricted Lambs Modifies Ruminal Fermentation but Does Not Improve Feed Efficiency
por: Martín, Alba, et al.
Publicado: (2022)

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung
por: Rafikova, Olga, et al.
Publicado: (2016)

Carnitine and Depression
por: Liu, Ting, et al.
Publicado: (2022)

Assessment of carnitine excretion and its ratio to plasma free carnitine as a biomarker for primary carnitine deficiency in newborns
por: Crefcoeur, Loek L., et al.
Publicado: (2022)

Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development
por: Rafikova, Olga, et al.
Publicado: (2019)

A new strategy to identify potentially dangerous coronary arterial patterns before percutaneous pulmonary valve implantation
por: Góreczny, Sebastian, et al.
Publicado: (2014)

Practical lambing and lamb care : a veterinary guide /
por: Eales, F. A., 1948-
Publicado: (2004)

Metabolic flexibility and carnitine flux: The role of carnitine acyltransferase in glucose homeostasis
por: Miyata, Yugo, et al.
Publicado: (2013)

Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis
por: Shimizu, Satoshi, et al.
Publicado: (2019)

Diseases of the Pulmonary Vascular System
por: Oishi, Peter, et al.
Publicado: (2008)

Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research
por: Oishi, Peter, et al.
Publicado: (2020)

Sex-specific stress response and HMGB1 release in pulmonary endothelial cells
por: Zemskova, Marina, et al.
Publicado: (2020)

The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients
por: Wang, Dong-Dong, et al.
Publicado: (2021)

Axial slices compared to short-axis slices for measurement of right and left ventricle volumes of patients with corrected Tetralogy of Fallot and Ebstein's anomaly by cardiac magnetic resonance
por: Fratz, Sohrab, et al.
Publicado: (2009)

Role of carnitine in disease
por: Flanagan, Judith L, et al.
Publicado: (2010)

Carnitine Deficiency and Pregnancy
por: de Bruyn, Anouk, et al.
Publicado: (2015)

Consumer Perception of the Quality of Lamb and Lamb Confit
por: Ripoll, Guillermo, et al.
Publicado: (2018)

Screening of free carnitine and acyl-carnitine status in patients with Familial Mediterranean Fever
por: Kiykim, E, et al.
Publicado: (2015)

Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise?
por: Gnoni, Antonio, et al.
Publicado: (2020)

Bio-Based Active Packaging: Carrageenan Film with Olive Leaf Extract for Lamb Meat Preservation
por: Martiny, Thamiris Renata, et al.
Publicado: (2020)

Long standing cyanosis in congenital heart disease does not cause diffuse myocardial fibrosis
por: Kharabish, Ahmed E, et al.
Publicado: (2014)

Molecular mechanisms of bio-catalysis of heme extraction from hemoglobin
por: Sakipov, Serzhan, et al.
Publicado: (2017)

Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality
por: Aliabadi, Elham, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tdemq98lppamovki6mmaijc8l0