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Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers
Polymerases ϵ and δ are the main enzymes that replicate eukaryotic DNA. Accurate replication occurs through Watson–Crick base pairing and also through the action of the polymerases' exonuclease (proofreading) domains. We have recently shown that germline exonuclease domain mutations (EDMs) of P...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley & Sons, Ltd
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709119/ https://www.ncbi.nlm.nih.gov/pubmed/23447401 http://dx.doi.org/10.1002/path.4185 |