Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

Oxidative stress is a determining factor of cellular senescence and aging and a potent inducer of the tumour-suppressor p53. Resistance to oxidative stress correlates with delayed aging in mammals, in the absence of accelerated tumorigenesis, suggesting inactivation of selected p53-downstream pathwa...

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Detalles Bibliográficos
Autores principales: Gambino, Valentina, De Michele, Giulia, Venezia, Oriella, Migliaccio, Pierluigi, Dall'Olio, Valentina, Bernard, Loris, Minardi, Simone Paolo, Fazia, Maria Agnese Della, Bartoli, Daniela, Servillo, Giuseppe, Alcalay, Myriam, Luzi, Lucilla, Giorgio, Marco, Scrable, Heidi, Pelicci, Pier Giuseppe, Migliaccio, Enrica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709138/
https://www.ncbi.nlm.nih.gov/pubmed/23448364
http://dx.doi.org/10.1111/acel.12060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709138/
https://www.ncbi.nlm.nih.gov/pubmed/23448364
http://dx.doi.org/10.1111/acel.12060

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