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On the Origins of Mendelian Disease Genes in Man: The Impact of Gene Duplication
Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically coming into existence with early metazoa. The appr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709195/ https://www.ncbi.nlm.nih.gov/pubmed/21705381 http://dx.doi.org/10.1093/molbev/msr111 |