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Applications of metabolomics in cancer research
The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attentio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709411/ https://www.ncbi.nlm.nih.gov/pubmed/23858297 http://dx.doi.org/10.4103/1477-3163.113622 |
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author | Vermeersch, Kathleen A. Styczynski, Mark P. |
author_facet | Vermeersch, Kathleen A. Styczynski, Mark P. |
author_sort | Vermeersch, Kathleen A. |
collection | PubMed |
description | The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics – which attempts to profile all metabolites within a cell or biological system – is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. While a large fraction of cancer metabolomics research is focused on finding diagnostic biomarkers, metabolomics is also being used to obtain more fundamental mechanistic insight into cancer and carcinogenesis. Applications of metabolomics are also emerging in areas such as tumor staging and assessment of treatment efficacy. This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field. |
format | Online Article Text |
id | pubmed-3709411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37094112013-07-15 Applications of metabolomics in cancer research Vermeersch, Kathleen A. Styczynski, Mark P. J Carcinog Review Article The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics – which attempts to profile all metabolites within a cell or biological system – is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. While a large fraction of cancer metabolomics research is focused on finding diagnostic biomarkers, metabolomics is also being used to obtain more fundamental mechanistic insight into cancer and carcinogenesis. Applications of metabolomics are also emerging in areas such as tumor staging and assessment of treatment efficacy. This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field. Medknow Publications & Media Pvt Ltd 2013-06-18 /pmc/articles/PMC3709411/ /pubmed/23858297 http://dx.doi.org/10.4103/1477-3163.113622 Text en Copyright: © 2013 Vermeersch http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vermeersch, Kathleen A. Styczynski, Mark P. Applications of metabolomics in cancer research |
title | Applications of metabolomics in cancer research |
title_full | Applications of metabolomics in cancer research |
title_fullStr | Applications of metabolomics in cancer research |
title_full_unstemmed | Applications of metabolomics in cancer research |
title_short | Applications of metabolomics in cancer research |
title_sort | applications of metabolomics in cancer research |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709411/ https://www.ncbi.nlm.nih.gov/pubmed/23858297 http://dx.doi.org/10.4103/1477-3163.113622 |
work_keys_str_mv | AT vermeerschkathleena applicationsofmetabolomicsincancerresearch AT styczynskimarkp applicationsofmetabolomicsincancerresearch |