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Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21
Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709480/ https://www.ncbi.nlm.nih.gov/pubmed/23748970 http://dx.doi.org/10.1038/ncomms2978 |