Loss of Vps54 Function Leads to Vesicle Traffic Impairment, Protein Mis-Sorting and Embryonic Lethality

The identification of the mutation causing the phenotype of the amyotrophic lateral sclerosis (ALS) model mouse, wobbler, has linked motor neuron degeneration with retrograde vesicle traffic. The wobbler mutation affects protein stability of Vps54, a ubiquitously expressed vesicle-tethering factor a...

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Detalles Bibliográficos
Autores principales: Karlsson, Páll, Droce, Aida, Moser, Jakob M., Cuhlmann, Simon, Padilla, Carolina Ortiz, Heimann, Peter, Bartsch, Jörg W., Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Schmitt-John, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709709/
https://www.ncbi.nlm.nih.gov/pubmed/23708095
http://dx.doi.org/10.3390/ijms140610908

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