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Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI

PCA3 (prostate cancer gene 3) and multiparametric 3 tesla MRI are new promising diagnostic tools in the detection of PCa. Our aim was to study the clinical value of the Progensa PCA3-test: its predictive value for biopsy outcome, Gleason score and MRI outcome. We evaluated, retrospectively, 591 pati...

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Autores principales: Leyten, Gisele H. J. M., Wierenga, Elisabeth A., Michiel Sedelaar, J. P., van Oort, Inge M., Futterer, Jurgen J., Barentsz, Jelle O., Schalken, Jack A., Mulders, Peter F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709735/
https://www.ncbi.nlm.nih.gov/pubmed/23759986
http://dx.doi.org/10.3390/ijms140611347
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author Leyten, Gisele H. J. M.
Wierenga, Elisabeth A.
Michiel Sedelaar, J. P.
van Oort, Inge M.
Futterer, Jurgen J.
Barentsz, Jelle O.
Schalken, Jack A.
Mulders, Peter F. A.
author_facet Leyten, Gisele H. J. M.
Wierenga, Elisabeth A.
Michiel Sedelaar, J. P.
van Oort, Inge M.
Futterer, Jurgen J.
Barentsz, Jelle O.
Schalken, Jack A.
Mulders, Peter F. A.
author_sort Leyten, Gisele H. J. M.
collection PubMed
description PCA3 (prostate cancer gene 3) and multiparametric 3 tesla MRI are new promising diagnostic tools in the detection of PCa. Our aim was to study the clinical value of the Progensa PCA3-test: its predictive value for biopsy outcome, Gleason score and MRI outcome. We evaluated, retrospectively, 591 patients who underwent a Progensa PCA3-test at the Radboud University Nijmegen Medical Centre between May 2006 and December 2009. Prostate biopsies were performed in 290 patients; a multiparametric 3 tesla MRI of the prostate was performed in 163/591 patients. The PCA3-score was correlated to biopsy results and MRI outcome. The results show that PCA3 was highly predictive for biopsy outcome (p < 0.001); there was no correlation with the Gleason score upon biopsy (p = 0.194). The PCA3-score of patients with a suspicious region for PCa on MRI was significantly higher (p < 0.001) than in patients with no suspicious region on MRI (52 vs. 21). In conclusion, PCA3 is a valuable diagnostic biomarker for PCa; it did not correlate with the Gleason score. Furthermore, multiparametric MRI outcome was significantly correlated with the PCA3-score. Thus, PCA3 could be used to select patients that require MRI. However, in patients with a negative PCA3 and high clinical suspicion of PCa, a multiparametric MRI should also be done.
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spelling pubmed-37097352013-07-12 Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI Leyten, Gisele H. J. M. Wierenga, Elisabeth A. Michiel Sedelaar, J. P. van Oort, Inge M. Futterer, Jurgen J. Barentsz, Jelle O. Schalken, Jack A. Mulders, Peter F. A. Int J Mol Sci Article PCA3 (prostate cancer gene 3) and multiparametric 3 tesla MRI are new promising diagnostic tools in the detection of PCa. Our aim was to study the clinical value of the Progensa PCA3-test: its predictive value for biopsy outcome, Gleason score and MRI outcome. We evaluated, retrospectively, 591 patients who underwent a Progensa PCA3-test at the Radboud University Nijmegen Medical Centre between May 2006 and December 2009. Prostate biopsies were performed in 290 patients; a multiparametric 3 tesla MRI of the prostate was performed in 163/591 patients. The PCA3-score was correlated to biopsy results and MRI outcome. The results show that PCA3 was highly predictive for biopsy outcome (p < 0.001); there was no correlation with the Gleason score upon biopsy (p = 0.194). The PCA3-score of patients with a suspicious region for PCa on MRI was significantly higher (p < 0.001) than in patients with no suspicious region on MRI (52 vs. 21). In conclusion, PCA3 is a valuable diagnostic biomarker for PCa; it did not correlate with the Gleason score. Furthermore, multiparametric MRI outcome was significantly correlated with the PCA3-score. Thus, PCA3 could be used to select patients that require MRI. However, in patients with a negative PCA3 and high clinical suspicion of PCa, a multiparametric MRI should also be done. Molecular Diversity Preservation International (MDPI) 2013-05-28 /pmc/articles/PMC3709735/ /pubmed/23759986 http://dx.doi.org/10.3390/ijms140611347 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Leyten, Gisele H. J. M.
Wierenga, Elisabeth A.
Michiel Sedelaar, J. P.
van Oort, Inge M.
Futterer, Jurgen J.
Barentsz, Jelle O.
Schalken, Jack A.
Mulders, Peter F. A.
Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title_full Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title_fullStr Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title_full_unstemmed Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title_short Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
title_sort value of pca3 to predict biopsy outcome and its potential role in selecting patients for multiparametric mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709735/
https://www.ncbi.nlm.nih.gov/pubmed/23759986
http://dx.doi.org/10.3390/ijms140611347
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