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Autophagy in Prostate Cancer and Androgen Suppression Therapy
The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cance...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709775/ https://www.ncbi.nlm.nih.gov/pubmed/23743823 http://dx.doi.org/10.3390/ijms140612090 |
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author | Ziparo, Elio Petrungaro, Simonetta Marini, Elettra Sara Starace, Donatella Conti, Silvia Facchiano, Antonio Filippini, Antonio Giampietri, Claudia |
author_facet | Ziparo, Elio Petrungaro, Simonetta Marini, Elettra Sara Starace, Donatella Conti, Silvia Facchiano, Antonio Filippini, Antonio Giampietri, Claudia |
author_sort | Ziparo, Elio |
collection | PubMed |
description | The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment. |
format | Online Article Text |
id | pubmed-3709775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37097752013-07-12 Autophagy in Prostate Cancer and Androgen Suppression Therapy Ziparo, Elio Petrungaro, Simonetta Marini, Elettra Sara Starace, Donatella Conti, Silvia Facchiano, Antonio Filippini, Antonio Giampietri, Claudia Int J Mol Sci Review The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment. Molecular Diversity Preservation International (MDPI) 2013-06-06 /pmc/articles/PMC3709775/ /pubmed/23743823 http://dx.doi.org/10.3390/ijms140612090 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Ziparo, Elio Petrungaro, Simonetta Marini, Elettra Sara Starace, Donatella Conti, Silvia Facchiano, Antonio Filippini, Antonio Giampietri, Claudia Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title | Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title_full | Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title_fullStr | Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title_full_unstemmed | Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title_short | Autophagy in Prostate Cancer and Androgen Suppression Therapy |
title_sort | autophagy in prostate cancer and androgen suppression therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709775/ https://www.ncbi.nlm.nih.gov/pubmed/23743823 http://dx.doi.org/10.3390/ijms140612090 |
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