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Autophagy in Prostate Cancer and Androgen Suppression Therapy

The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cance...

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Autores principales: Ziparo, Elio, Petrungaro, Simonetta, Marini, Elettra Sara, Starace, Donatella, Conti, Silvia, Facchiano, Antonio, Filippini, Antonio, Giampietri, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709775/
https://www.ncbi.nlm.nih.gov/pubmed/23743823
http://dx.doi.org/10.3390/ijms140612090
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author Ziparo, Elio
Petrungaro, Simonetta
Marini, Elettra Sara
Starace, Donatella
Conti, Silvia
Facchiano, Antonio
Filippini, Antonio
Giampietri, Claudia
author_facet Ziparo, Elio
Petrungaro, Simonetta
Marini, Elettra Sara
Starace, Donatella
Conti, Silvia
Facchiano, Antonio
Filippini, Antonio
Giampietri, Claudia
author_sort Ziparo, Elio
collection PubMed
description The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.
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spelling pubmed-37097752013-07-12 Autophagy in Prostate Cancer and Androgen Suppression Therapy Ziparo, Elio Petrungaro, Simonetta Marini, Elettra Sara Starace, Donatella Conti, Silvia Facchiano, Antonio Filippini, Antonio Giampietri, Claudia Int J Mol Sci Review The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment. Molecular Diversity Preservation International (MDPI) 2013-06-06 /pmc/articles/PMC3709775/ /pubmed/23743823 http://dx.doi.org/10.3390/ijms140612090 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ziparo, Elio
Petrungaro, Simonetta
Marini, Elettra Sara
Starace, Donatella
Conti, Silvia
Facchiano, Antonio
Filippini, Antonio
Giampietri, Claudia
Autophagy in Prostate Cancer and Androgen Suppression Therapy
title Autophagy in Prostate Cancer and Androgen Suppression Therapy
title_full Autophagy in Prostate Cancer and Androgen Suppression Therapy
title_fullStr Autophagy in Prostate Cancer and Androgen Suppression Therapy
title_full_unstemmed Autophagy in Prostate Cancer and Androgen Suppression Therapy
title_short Autophagy in Prostate Cancer and Androgen Suppression Therapy
title_sort autophagy in prostate cancer and androgen suppression therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709775/
https://www.ncbi.nlm.nih.gov/pubmed/23743823
http://dx.doi.org/10.3390/ijms140612090
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