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UV Radiation and the Skin

UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other envi...

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Autores principales: D’Orazio, John, Jarrett, Stuart, Amaro-Ortiz, Alexandra, Scott, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709783/
https://www.ncbi.nlm.nih.gov/pubmed/23749111
http://dx.doi.org/10.3390/ijms140612222
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author D’Orazio, John
Jarrett, Stuart
Amaro-Ortiz, Alexandra
Scott, Timothy
author_facet D’Orazio, John
Jarrett, Stuart
Amaro-Ortiz, Alexandra
Scott, Timothy
author_sort D’Orazio, John
collection PubMed
description UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.
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spelling pubmed-37097832013-07-12 UV Radiation and the Skin D’Orazio, John Jarrett, Stuart Amaro-Ortiz, Alexandra Scott, Timothy Int J Mol Sci Review UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance. Molecular Diversity Preservation International (MDPI) 2013-06-07 /pmc/articles/PMC3709783/ /pubmed/23749111 http://dx.doi.org/10.3390/ijms140612222 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
D’Orazio, John
Jarrett, Stuart
Amaro-Ortiz, Alexandra
Scott, Timothy
UV Radiation and the Skin
title UV Radiation and the Skin
title_full UV Radiation and the Skin
title_fullStr UV Radiation and the Skin
title_full_unstemmed UV Radiation and the Skin
title_short UV Radiation and the Skin
title_sort uv radiation and the skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709783/
https://www.ncbi.nlm.nih.gov/pubmed/23749111
http://dx.doi.org/10.3390/ijms140612222
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