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Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction
The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent yields. A plausible sulfonylation/desulfinati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709795/ https://www.ncbi.nlm.nih.gov/pubmed/23765221 http://dx.doi.org/10.3390/ijms140612484 |
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author | Han, Jintao Dong, Hongbo Xu, Zhihong Lei, Jianping Wang, Mingan |
author_facet | Han, Jintao Dong, Hongbo Xu, Zhihong Lei, Jianping Wang, Mingan |
author_sort | Han, Jintao |
collection | PubMed |
description | The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent yields. A plausible sulfonylation/desulfination mechanism was proposed. The bioassay showed that these compounds exhibit certain fungicidal activities with the 71.9% inhibition rate of 2K against B. cinerea, and 57.6% inhibition rate of 2m against A. solani, respectively. |
format | Online Article Text |
id | pubmed-3709795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37097952013-07-12 Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction Han, Jintao Dong, Hongbo Xu, Zhihong Lei, Jianping Wang, Mingan Int J Mol Sci Article The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent yields. A plausible sulfonylation/desulfination mechanism was proposed. The bioassay showed that these compounds exhibit certain fungicidal activities with the 71.9% inhibition rate of 2K against B. cinerea, and 57.6% inhibition rate of 2m against A. solani, respectively. Molecular Diversity Preservation International (MDPI) 2013-06-13 /pmc/articles/PMC3709795/ /pubmed/23765221 http://dx.doi.org/10.3390/ijms140612484 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Han, Jintao Dong, Hongbo Xu, Zhihong Lei, Jianping Wang, Mingan Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title | Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title_full | Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title_fullStr | Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title_full_unstemmed | Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title_short | Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction |
title_sort | facile synthesis of 5-arylidene thiohydantoin by sequential sulfonylation/desulfination reaction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709795/ https://www.ncbi.nlm.nih.gov/pubmed/23765221 http://dx.doi.org/10.3390/ijms140612484 |
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